Uses & Benefits
Treatment of anxiety disorders, short-term relief of severe anxiety symptoms, panic disorder (with or without agoraphobia)
How It Works
Alprazolam is a benzodiazepine that enhances the effect of GABA, a calming neurotransmitter in the brain. This reduces excessive nerve activity, producing anxiolytic and sedative effects.
Directions for Use
Take exactly as prescribed by the doctor. Usually taken by mouth with or without food; take at the same time each day. Do not stop suddenly—dose should be tapered gradually to avoid withdrawal. Avoid driving or operating machinery if drowsy.
Side Effects
Drowsiness, dizziness, fatigue, impaired coordination, memory problems, confusion, headache, blurred vision, dry mouth, nausea, constipation
Warnings & Precautions
Risk of dependence, abuse and withdrawal (may be severe if stopped abruptly). May cause sedation, impaired alertness and falls—avoid driving/alcohol. Use with caution in elderly, liver disease, respiratory disease (COPD/sleep apnea), depression or suicidal thoughts, and history of substance misuse. Concomitant use with opioids or other CNS depressants can cause profound sedation, respiratory depression, coma or death. Not recommended for long-term continuous use unless advised by specialist.
Drug Interactions
Alcohol, opioids (e.g., morphine, codeine, tramadol), other sedatives (sleeping pills, antihistamines like chlorpheniramine, antipsychotics), antidepressants, strong CYP3A4 inhibitors (ketoconazole, itraconazole, clarithromycin, erythromycin, ritonavir), grapefruit/grapefruit juice, valproate, diltiazem/verapamil