TOLOL AM 25

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Treatment of depression; also used for neuropathic (nerve) pain, chronic pain conditions, and prevention of migraine/tension-type headache (as prescribed).

Amitriptyline is a tricyclic antidepressant that increases levels of serotonin and noradrenaline in the brain by inhibiting their reuptake. This helps improve mood and also modulates pain pathways, reducing nerve-related pain.

Tablet for oral use. Take exactly as prescribed, usually once daily (often at bedtime due to drowsiness) with or without food. Swallow whole with water; do not stop suddenly without medical advice.

Drowsiness, dizziness, dry mouth, constipation, blurred vision, weight gain, nausea, difficulty in urination, increased appetite

May cause marked drowsiness—avoid driving or operating machinery. Use with caution in heart disease/arrhythmias, glaucoma, urinary retention/prostate enlargement, thyroid disorders, epilepsy, liver disease, and in the elderly (risk of falls/confusion). Do not use with MAO inhibitors or within 14 days of stopping them. May increase risk of suicidal thoughts in young adults—monitor mood changes. Do not stop abruptly; taper as advised.

MAO inhibitors (contraindicated), alcohol and other CNS depressants (increased sedation), SSRIs/SNRIs (serotonin syndrome risk), tramadol/linezolid/methylene blue (serotonin syndrome risk), anticholinergics (additive side effects), antihypertensives (enhanced hypotension), QT-prolonging drugs/antiarrhythmics (arrhythmia risk), carbamazepine (reduced levels), cimetidine (increased levels)