Zoryl M 0.5 Tablet

Zoryl M 0.5 Tablet contains Glimepiride (0.5mg). Prescription required.

Type 2 diabetes mellitus in adults when diet and exercise alone are not sufficient; helps control high blood sugar, usually as add-on/combination therapy.

Glimepiride (a sulfonylurea) stimulates the pancreas to release insulin and improves peripheral glucose utilization. Metformin (a biguanide) decreases glucose production in the liver and improves insulin sensitivity, lowering blood glucose without usually causing weight gain.

Take by mouth as prescribed, usually once daily with the main meal (preferably breakfast) to reduce stomach upset and risk of low sugar. Swallow whole (do not crush/chew if prolonged-release). Monitor blood glucose regularly; do not stop abruptly without medical advice.

Hypoglycaemia (low blood sugar), nausea, vomiting, diarrhoea, abdominal pain, loss of appetite, metallic taste, headache, dizziness, weight gain, skin rash

Risk of hypoglycaemia (more with missed meals, alcohol, excessive exercise, kidney/liver impairment); carry a fast-acting glucose source. Metformin may rarely cause lactic acidosis—seek urgent help for rapid breathing, severe weakness, muscle pain, abdominal pain, or unusual sleepiness; higher risk with significant kidney disease, dehydration, severe infection, heart/respiratory failure. Avoid in severe renal impairment; dose adjustment/monitoring needed in kidney disease and elderly. Hold metformin around iodinated contrast procedures and major surgery as advised by doctor. Use caution in liver disease; monitor HbA1c and renal function periodically.

Alcohol, insulin and other antidiabetics (additive hypoglycaemia), beta-blockers (may mask hypoglycaemia symptoms), ACE inhibitors (may enhance glucose-lowering), corticosteroids and thiazide/loop diuretics (may raise glucose), rifampicin (may reduce glimepiride effect), azole antifungals/macrolides/fluoroquinolones (may increase hypoglycaemia risk), NSAIDs and salicylates (may increase sulfonylurea effect), iodinated contrast media (lactic acidosis risk with metformin), cimetidine (may increase metformin levels)

Store below 25°C in a cool, dry place. Protect from moisture and light. Keep out of reach of children.

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