Type 2 diabetes mellitus in adults when diet and exercise alone are not sufficient; helps control high blood sugar, usually as add-on/combination therapy.
How It Works
Glimepiride (a sulfonylurea) stimulates the pancreas to release insulin and improves peripheral glucose utilization. Metformin (a biguanide) decreases glucose production in the liver and improves insulin sensitivity, lowering blood glucose without usually causing weight gain.
Directions for Use
Take by mouth as prescribed, usually once daily with the main meal (preferably breakfast) to reduce stomach upset and risk of low sugar. Swallow whole (do not crush/chew if prolonged-release). Monitor blood glucose regularly; do not stop abruptly without medical advice.
Side Effects
Hypoglycaemia (low blood sugar), nausea, vomiting, diarrhoea, abdominal pain, loss of appetite, metallic taste, headache, dizziness, weight gain, skin rash
Warnings & Precautions
Risk of hypoglycaemia (more with missed meals, alcohol, excessive exercise, kidney/liver impairment); carry a fast-acting glucose source. Metformin may rarely cause lactic acidosis—seek urgent help for rapid breathing, severe weakness, muscle pain, abdominal pain, or unusual sleepiness; higher risk with significant kidney disease, dehydration, severe infection, heart/respiratory failure. Avoid in severe renal impairment; dose adjustment/monitoring needed in kidney disease and elderly. Hold metformin around iodinated contrast procedures and major surgery as advised by doctor. Use caution in liver disease; monitor HbA1c and renal function periodically.
Drug Interactions
Alcohol, insulin and other antidiabetics (additive hypoglycaemia), beta-blockers (may mask hypoglycaemia symptoms), ACE inhibitors (may enhance glucose-lowering), corticosteroids and thiazide/loop diuretics (may raise glucose), rifampicin (may reduce glimepiride effect), azole antifungals/macrolides/fluoroquinolones (may increase hypoglycaemia risk), NSAIDs and salicylates (may increase sulfonylurea effect), iodinated contrast media (lactic acidosis risk with metformin), cimetidine (may increase metformin levels)
Storage Instructions
Store below 25°C in a cool, dry place. Protect from moisture and light. Keep out of reach of children.
Substitutes
Amaryl M 0.5/500 Tablet, Glycomet GP 0.5/500 Tablet, Glimy M 0.5/500 Tablet, Gluconorm-G 0.5/500 Tablet, Gemer M 0.5/500 Tablet
Frequently Asked Questions
What is this medicine used for?
Type 2 diabetes mellitus in adults when diet and exercise alone are not sufficient; helps control high blood sugar, usually as add-on/combination therapy.
What are the side effects?
Hypoglycaemia (low blood sugar), nausea, vomiting, diarrhoea, abdominal pain, loss of appetite, metallic taste, headache, dizziness, weight gain, skin rash
How does this medicine work?
Glimepiride (a sulfonylurea) stimulates the pancreas to release insulin and improves peripheral glucose utilization. Metformin (a biguanide) decreases glucose production in the liver and improves insulin sensitivity, lowering blood glucose without usually causing weight gain.
How should I use this medicine?
Take by mouth as prescribed, usually once daily with the main meal (preferably breakfast) to reduce stomach upset and risk of low sugar. Swallow whole (do not crush/chew if prolonged-release). Monitor blood glucose regularly; do not stop abruptly without medical advice.
How should I store this medicine?
Store below 25°C in a cool, dry place. Protect from moisture and light. Keep out of reach of children.
Do I need a prescription for this product?
Yes, this product requires a valid prescription (Rx). Upload it during checkout when prompted.
Can prices or availability change?
Yes. Prices and availability can change based on inventory and serviceability. The latest details are shown at checkout.
How do I place an order?
Select a variant, add to cart, enter delivery address, upload prescription if required, and pay securely.
Manufacturer & Brand
Brand:Intas Pharmaceuticals Ltd
Manufacturer:INTAS PHARMACEUTICALS`
HSN Code:30049099
Alternatives
Alternatives are suggested by pharmacists after reviewing your order and prescription.
Disclaimer: Product information is for awareness only and does not replace medical advice. For Rx medicines, a valid prescription is required. Consult your doctor or pharmacist for personalized guidance.
Sources: Manufacturer labeling/pack insert, CDSCO guidance on antidiabetics, established medical literature (standard pharmacology texts), Indian Pharmacopoeia monographs for APIs