Zuvirab Injection

Zuvirab Injection contains Rabies vaccine (inactivated) (Purified Vero Cell Rabies Vaccine, PVRV) 2.5 IU per 0.5 mL vial (with diluent). Prescription required.

Prevention of rabies (immunization) for pre-exposure prophylaxis (PrEP) in high-risk individuals and post-exposure prophylaxis (PEP) after suspected/confirmed exposure to rabies.

This inactivated rabies vaccine stimulates the immune system to produce rabies virus neutralizing antibodies. These antibodies help prevent the rabies virus from establishing infection after exposure and provide protection in high-risk individuals.

For intramuscular use only; administer as per national/doctor-recommended schedule for PrEP or PEP. Common IM site: deltoid in adults/children (anterolateral thigh in small children); do not inject into gluteal region. Reconstitute with supplied diluent and use immediately after reconstitution; complete the full course. In PEP, rabies immunoglobulin may also be required for category III exposures as advised by a clinician.

Injection site pain, redness, swelling, fever, headache, dizziness, nausea, vomiting, abdominal pain, fatigue, muscle aches, joint pain, rash

Do not use in persons with known hypersensitivity to any component of the vaccine; seek medical help for severe allergic reaction (anaphylaxis). In PEP, vaccination should not be delayed; for PrEP, defer vaccination during acute severe febrile illness if possible. Use with caution in immunocompromised patients (may need antibody titre testing/extra doses). Keep emergency treatment for anaphylaxis available. Follow local guidelines for wound washing and vaccination schedule for exposures.

Immunosuppressants (e.g., high-dose corticosteroids, chemotherapy, biologics) may reduce vaccine response; avoid administering immunoglobulin in the same syringe or at the same site as vaccine; other vaccines may be given at separate sites as per clinician advice.

Store refrigerated at 2°C to 8°C; do not freeze. Protect from light. After reconstitution, use immediately and discard any unused portion.

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