Drug | Tablet

Dual antiplatelet therapy for acute coronary syndrome, prevention of stent thrombosis after PCI, secondary prevention of heart attack and ischemic stroke when advised by cardiologist

Aspirin inhibits COX-1 and reduces thromboxane A2 formation, lowering platelet aggregation. Clopidogrel blocks platelet P2Y12 receptors; together they provide stronger clot prevention than either alone.

Take as prescribed, usually once daily with water, preferably after food to reduce gastric irritation; do not crush/chew unless advised; do not stop abruptly without cardiologist advice.

Bleeding, bruising, heartburn, stomach pain, nausea, nosebleed, indigestion

Higher bleeding risk with dual therapy; seek urgent care for severe headache, black stools, vomiting blood, or uncontrolled bleeding. Avoid in active peptic ulcer/bleeding, aspirin allergy, severe asthma triggered by NSAIDs, severe liver disease. Inform doctor before surgery/dental work. Monitor for GI irritation/ulcer; may need gastroprotection as advised.

Anticoagulants (warfarin, DOACs), NSAIDs, other antiplatelets, SSRIs/SNRIs, corticosteroids, methotrexate (aspirin can increase toxicity), PPIs (omeprazole/esomeprazole reduce clopidogrel effect), alcohol (increases GI bleed risk)

Store below 30°C in a dry place, away from heat, light and moisture.

Deplatt A 75 Capsule, Clopivas AP 75 Capsule, Ecospirin Gold 75 Capsule, Plagril A 75 Capsule, Clopilet A 75 Capsule