Drug | Injection

Severe allergic reactions, acute inflammatory conditions, asthma/COPD exacerbations, autoimmune disorders, cerebral edema, adjunct antiemetic in chemotherapy (as prescribed).

Dexamethasone is a synthetic glucocorticoid that decreases inflammation by suppressing cytokines and inflammatory mediator release. It also reduces swelling by decreasing capillary leakage and tissue edema.

Administered only by a healthcare professional via IV/IM. Dose is individualized; if used beyond a short course, dose should be tapered. Follow hospital/doctor instructions strictly.

Hyperglycemia, indigestion, fluid retention, mood changes, insomnia, increased appetite, elevated blood pressure, injection-site reactions

Increases risk of infection and may mask infection symptoms; avoid live vaccines. Long-term use can cause adrenal suppression and bone loss; do not stop suddenly. Use caution in diabetes, hypertension, peptic ulcer, glaucoma, osteoporosis and tuberculosis history.

Rifampicin/phenytoin/carbamazepine (decrease effect), ketoconazole/erythromycin (increase effect), NSAIDs (GI ulcer/bleed), warfarin (INR changes), diuretics (hypokalemia), antidiabetic drugs (dose adjustment needed), live vaccines (avoid)

Store below 25°C, protect from light, do not freeze.

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