Prescription requiredAntitussive (Cough suppressant)

Benadryl DR Cough Syrup — Side Effects & Warnings

Known side effects of Benadryl DR Cough Syrup include Drowsiness, dizziness, nausea, vomiting, stomach upset, constipation, dry mouth. Not everyone experiences these side effects.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated June 2026

Common Side Effects

Drowsiness
dizziness
nausea
vomiting
stomach upset
constipation
dry mouth

This is not an exhaustive list. Consult your doctor if you notice any unusual symptoms.

Important Warnings

Do not use in children below the age recommended on the label without medical advice. Avoid driving or operating machinery if drowsy. Do not use for cough with excessive mucus, chronic cough (asthma/COPD/smoking), or if fever/rash/persistent symptoms occur—seek medical advice. Risk of misuse/overdose; do not exceed dose. Use caution in liver disease. Seek urgent care for serotonin syndrome symptoms (agitation, confusion, sweating, fast heartbeat, tremor) especially if on serotonergic medicines.

Drug Interactions

Benadryl DR Cough Syrup may interact with the following:

MAO inhibitors (e.g.
selegiline
linezolid) and within 14 days of stopping them
SSRIs/SNRIs/TCAs (risk of serotonin syndrome)
other CNS depressants (alcohol
sedatives)
serotonergic agents (tramadol
triptans)
CYP2D6 inhibitors (e.g.
fluoxetine
paroxetine
quinidine) may increase effects

Always tell your doctor about all medicines you are taking, including over-the-counter drugs and supplements.

Pregnancy Safety

Consult doctor

Alcohol Interaction

Avoid

Habit Forming

Storage

Store below 25°C in a cool, dry place. Protect from light. Keep the bottle tightly closed. Keep out of reach of children.

Benadryl DR Cough Syrup — Safety Summary

Composition: Dextromethorphan Hydrobromide 10 mg/5 ml
Prescription: Required (Rx)
Pregnancy: Consult doctor
Alcohol: Avoid
Habit forming: No

Benadryl DR Cough Syrup — Safety FAQs

What should I do if I experience side effects?

Mild side effects often resolve on their own. If side effects are severe or persistent, stop the medicine and consult your doctor immediately.

Are all listed side effects common?

No. Some side effects are common while others are rare. Not everyone experiences side effects. Consult your doctor if you are concerned.

Can I take this medicine with other drugs?

Some medicines interact with each other. Always inform your doctor about all medicines you are currently taking.

When should I seek emergency help?

Seek immediate medical attention if you experience severe allergic reactions (difficulty breathing, swelling of face/throat), chest pain, or any life-threatening symptoms.

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Safety disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice. If you experience severe side effects, seek medical attention immediately.