Prescription requiredSedative/Anxiolytic (Anesthetic adjunct)

Mezolam Injection — Side Effects & Warnings

Known side effects of Mezolam Injection include Drowsiness,sedation,dizziness,confusion,amnesia,low blood pressure,slow/irregular breathing,apnea,nausea,vomiting,injection site pain. Not everyone experiences these side effects.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated June 2026

Common Side Effects

Drowsiness
sedation
dizziness
confusion
amnesia
low blood pressure
slow/irregular breathing
apnea
nausea
vomiting
injection site pain

This is not an exhaustive list. Consult your doctor if you notice any unusual symptoms.

Important Warnings

Schedule H1 medicine: use only on prescription under medical supervision. Can cause profound sedation, respiratory depression, apnea and hypotension—higher risk with opioids, alcohol, other sedatives, elderly, debilitated patients, sleep apnea, COPD or severe illness. Use caution in liver impairment; effects may be prolonged. Risk of paradoxical reactions (agitation, aggression) and anterograde amnesia. Potential for dependence/withdrawal with prolonged or repeated use; taper if used for extended periods. Not recommended to self-administer.

Drug Interactions

Mezolam Injection may interact with the following:

Opioids (morphine
fentanyl
codeine
tramadol) and other CNS depressants (alcohol
antihistamines
antipsychotics
sedative antidepressants) increase respiratory depression. CYP3A4 inhibitors (ketoconazole
itraconazole
fluconazole
clarithromycin
erythromycin
ritonavir/cobicistat
grapefruit) increase midazolam levels; CYP3A4 inducers (rifampicin
carbamazepine
phenytoin
phenobarbital
St John’s wort) reduce effect. Caution with antihypertensives due to hypotension.

Always tell your doctor about all medicines you are taking, including over-the-counter drugs and supplements.

Pregnancy Safety

Use with caution / Consult doctor (generally avoid unless clearly needed; may affect newborn if used near delivery)

Alcohol Interaction

Avoid (can markedly increase sedation and breathing problems)

Habit Forming

Yes

Storage

Store below 25°C in original carton, protected from light. Do not freeze. Keep out of reach of children.

Mezolam Injection — Safety Summary

Composition: Midazolam 1 mg/mL (10 mL vial)
Prescription: Required (Rx)
Pregnancy: Use with caution / Consult doctor (generally avoid unless clearly needed; may affect newborn if used near delivery)
Alcohol: Avoid (can markedly increase sedation and breathing problems)
Habit forming: Yes

Mezolam Injection — Safety FAQs

What should I do if I experience side effects?

Mild side effects often resolve on their own. If side effects are severe or persistent, stop the medicine and consult your doctor immediately.

Are all listed side effects common?

No. Some side effects are common while others are rare. Not everyone experiences side effects. Consult your doctor if you are concerned.

Can I take this medicine with other drugs?

Some medicines interact with each other. Always inform your doctor about all medicines you are currently taking.

When should I seek emergency help?

Seek immediate medical attention if you experience severe allergic reactions (difficulty breathing, swelling of face/throat), chest pain, or any life-threatening symptoms.

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Safety disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice. If you experience severe side effects, seek medical attention immediately.