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Zyloric 300 Tablet — Side Effects & Warnings

Known side effects of Zyloric 300 Tablet include Skin rash, nausea, vomiting, diarrhoea, abdominal pain, headache, dizziness, drowsiness, taste changes, elevated liver enzymes. Not everyone experiences these side effects.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated June 2026

Common Side Effects

Skin rash
nausea
vomiting
diarrhoea
abdominal pain
headache
dizziness
drowsiness
taste changes
elevated liver enzymes

This is not an exhaustive list. Consult your doctor if you notice any unusual symptoms.

Important Warnings

Do not use if allergic to allopurinol. Stop and seek urgent medical help if rash, fever, sore throat, mouth ulcers, facial swelling, or peeling skin occurs (risk of severe cutaneous adverse reactions including SJS/TEN/DRESS). Use with caution in kidney or liver disease; dose adjustment may be required and monitoring advised. May precipitate an acute gout attack when started—doctor may prescribe prophylaxis (e.g., colchicine/NSAID). Maintain adequate fluid intake; monitor uric acid. Risk of hypersensitivity is higher in renal impairment and with thiazide diuretics; HLA-B*58:01 testing may be considered in high-risk ethnic groups.

Drug Interactions

Zyloric 300 Tablet may interact with the following:

Azathioprine
mercaptopurine (require major dose reduction/avoid)
warfarin (may increase effect)
theophylline
didanosine
cyclophosphamide/chlorpropamide (increased toxicity risk)
ampicillin/amoxicillin (increased rash risk)
thiazide diuretics (increased hypersensitivity risk)
ACE inhibitors (reported increased hypersensitivity)
probenecid/uricosurics (may alter levels)

Always tell your doctor about all medicines you are taking, including over-the-counter drugs and supplements.

Pregnancy Safety

Consult doctor (use only if clearly needed; limited human data)

Alcohol Interaction

Use with caution (alcohol can increase uric acid and worsen gout)

Habit Forming

Storage

Store at room temperature (below 25°C), protected from moisture and light. Keep in original pack and out of reach of children.

Zyloric 300 Tablet — Safety Summary

Composition: Allopurinol (300mg)
Prescription: Required (Rx)
Pregnancy: Consult doctor (use only if clearly needed; limited human data)
Alcohol: Use with caution (alcohol can increase uric acid and worsen gout)
Habit forming: No

Zyloric 300 Tablet — Safety FAQs

What should I do if I experience side effects?

Mild side effects often resolve on their own. If side effects are severe or persistent, stop the medicine and consult your doctor immediately.

Are all listed side effects common?

No. Some side effects are common while others are rare. Not everyone experiences side effects. Consult your doctor if you are concerned.

Can I take this medicine with other drugs?

Some medicines interact with each other. Always inform your doctor about all medicines you are currently taking.

When should I seek emergency help?

Seek immediate medical attention if you experience severe allergic reactions (difficulty breathing, swelling of face/throat), chest pain, or any life-threatening symptoms.

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Safety disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice. If you experience severe side effects, seek medical attention immediately.