Drug | Tablet

Edema (fluid retention) due to heart failure, liver cirrhosis or kidney disease, Hypertension (high blood pressure), Primary hyperaldosteronism, Hypokalemia prevention/treatment

Spironolactone is a potassium-sparing diuretic and aldosterone antagonist. It blocks aldosterone receptors in the kidney, increasing sodium and water excretion while conserving potassium, thereby reducing fluid overload and blood pressure.

Take exactly as prescribed by your doctor. Usually taken orally once daily or in divided doses; take with food to improve absorption and reduce stomach upset. Take at the same time each day; avoid potassium supplements/salt substitutes unless advised.

Hyperkalemia, nausea, vomiting, diarrhea, abdominal cramps, dizziness, headache, fatigue, gynecomastia, breast tenderness, menstrual irregularities, decreased libido, rash

Risk of high potassium (hyperkalemia), especially in kidney disease, diabetes, dehydration, or when combined with ACE inhibitors/ARBs or potassium supplements. Avoid in severe kidney impairment, anuria, Addison’s disease, or known hyperkalemia. Monitor serum potassium, sodium and kidney function regularly. May cause dizziness; use caution while driving. Use caution in liver disease.

ACE inhibitors (e.g., enalapril), ARBs (e.g., losartan), aliskiren, potassium supplements/salt substitutes, other potassium-sparing diuretics (amiloride, triamterene), NSAIDs (ibuprofen, diclofenac), lithium, digoxin, trimethoprim/cotrimoxazole, heparin/LMWH

Store below 25°C, protected from moisture and light. Keep in original pack and out of reach of children.

Aldactone 50 Tablet, Spiractin 25 Tablet, Spironolactone 25 mg Tablet (generic), Spleenact 25 Tablet, Verospiron 25 Tablet