Other anticoagulants/antiplatelets (warfarin, heparin, aspirin, clopidogrel), NSAIDs (ibuprofen, naproxen), SSRIs/SNRIs (sertraline, fluoxetine, venlafaxine) increasing bleeding risk, Strong CYP3A4 and P-gp inhibitors (ketoconazole, itraconazole, ritonavir, clarithromycin) may increase apixaban levels, Strong CYP3A4 and P-gp inducers (rifampicin, carbamazepine, phenytoin, phenobarbital, St John’s wort) may reduce effect