Drug | Tablet

Epilepsy/seizure disorders, bipolar disorder (mania) as prescribed, prevention of migraine (selected patients as prescribed)

Valproate increases inhibitory GABA neurotransmission and reduces abnormal electrical activity in the brain. Prolonged release helps maintain stable plasma concentrations for ongoing seizure and mood control.

Take as prescribed with food if needed. Swallow whole; do not crush or chew prolonged-release tablets. Do not stop abruptly; periodic lab monitoring (LFTs, CBC) may be needed.

Nausea, vomiting, abdominal pain, tremor, drowsiness, dizziness, weight gain, hair loss, increased appetite

Not recommended in pregnancy; high teratogenic risk and developmental harm. Risk of serious liver injury, pancreatitis, hyperammonemia and low platelets; watch for jaundice, severe abdominal pain, vomiting, bruising/bleeding or altered sensorium. Use caution in liver disease and mitochondrial disorders.

Lamotrigine (increased levels and rash risk), carbamazepine/phenytoin/phenobarbital (altered levels), topiramate (hyperammonemia), warfarin/antiplatelets (bleeding), aspirin (increased valproate), alcohol and sedatives (added CNS depression)

Store below 25°C, in a dry place, away from light.

Encorate Chrono 200 Tablet, Encorate Chrono 400 Tablet