Drug | Tablet

Epilepsy (generalized and focal seizures), prevention of migraine (as prescribed), bipolar disorder/mania (as prescribed)

Controlled-release valproate increases brain GABA activity and reduces excessive neuronal firing. The chrono/CR formulation releases medicine gradually to maintain steadier blood levels.

Take with food at the same time each day. Swallow whole; do not crush or chew controlled-release tablets. Do not stop suddenly; follow your doctor’s titration schedule.

Nausea, indigestion, abdominal pain, diarrhea, increased appetite, weight gain, tremor, drowsiness, dizziness, hair loss

Risk of serious liver injury and pancreatitis; monitor for jaundice, severe abdominal pain, persistent vomiting. High risk in pregnancy (major birth defects and developmental delay); ensure effective contraception and specialist review. Monitor liver function tests and blood counts; caution with bleeding tendency. May cause sedation; avoid driving if affected.

Lamotrigine (higher levels and rash risk), carbamazepine, phenytoin, phenobarbital, topiramate (hyperammonemia), warfarin/anticoagulants (bleeding), aspirin (bleeding and increased valproate), alcohol and sedatives (increased drowsiness)

Store below 25°C, protected from light and moisture. Keep in original pack.

Epilex Chrono 300 Tablet