Humiglim M2 Dapa Tab

Tablet

Type 2 diabetes mellitus—adjunct to diet and exercise to improve glycaemic control in adults when dual/monotherapy is inadequate.

Glimepiride (sulfonylurea) increases insulin release from pancreatic beta cells. Metformin reduces hepatic glucose production and improves insulin sensitivity. Dapagliflozin (SGLT2 inhibitor) increases urinary glucose excretion by reducing glucose reabsorption in the kidneys.

Oral tablet; take exactly as prescribed. Usually taken once daily with food (preferably with breakfast) to reduce stomach upset and hypoglycaemia risk; swallow whole with water. Regularly monitor blood glucose; do not stop or change dose without medical advice.

Hypoglycaemia, dizziness, headache, nausea, diarrhoea, abdominal pain, loss of appetite, genital fungal infection, urinary tract infection, increased urination, thirst

Prescription-only antidiabetic. Risk of hypoglycaemia (higher with missed meals, alcohol, strenuous exercise, elderly, renal/hepatic impairment). Metformin: rare lactic acidosis risk—avoid in severe kidney disease, severe liver disease, hypoxia, dehydration; temporarily stop before/after iodinated contrast and major surgery as advised. Dapagliflozin: risk of genital mycotic infections, UTIs, dehydration/low BP, ketoacidosis (can occur with near-normal glucose), acute kidney injury; maintain hydration and stop during acute illness/fasting/surgery per clinician advice. Monitor renal function, HbA1c, and signs of infection; use caution in heart failure/diuretics. Not for type 1 diabetes or diabetic ketoacidosis.

Insulin/other antidiabetics (increased hypoglycaemia risk), diuretics (dehydration/hypotension risk with dapagliflozin), ACE inhibitors/ARBs/NSAIDs (may affect kidney function), corticosteroids and thyroid hormones (raise glucose), rifampicin (may reduce glimepiride effect), azole antifungals/clarithromycin (may increase sulfonylurea effect), alcohol (hypoglycaemia and lactic acidosis risk), iodinated contrast media (lactic acidosis risk with metformin)

Store below 25°C in a dry place, protected from light and moisture. Keep in original blister pack and out of reach of children.

Glycomet GP 2 D 10 Tablet, Glimiprex M2 D 10 Tablet, Amaryl M 2 + Dapa 10 Tablet, Glimepiride Metformin Dapagliflozin 2/500/10 mg tablets (generic equivalents), Zoryl M2 D 10 Tablet