Drug | Tablet

Type 2 diabetes mellitus (non-insulin-dependent) in adults, when diet and exercise alone are not sufficient; helps control blood glucose levels and reduce diabetes-related complications.

Gliclazide is a sulfonylurea that stimulates insulin release from pancreatic beta cells by closing ATP-sensitive potassium channels. This increases insulin secretion and helps lower blood glucose, mainly by improving post-meal and fasting glucose control.

Tablet for oral use. Take exactly as prescribed, usually once or twice daily with food (commonly with breakfast and/or evening meal) to reduce risk of hypoglycaemia. Swallow whole with water; do not skip meals. Regularly monitor blood glucose.

Hypoglycaemia (low blood sugar), nausea, abdominal pain, indigestion, diarrhoea, headache, dizziness, weight gain, skin rash/itching

May cause hypoglycaemia, especially with missed meals, excessive exercise, alcohol intake, or with other antidiabetic medicines; carry glucose/sugar source. Use with caution in elderly, malnourished patients, adrenal/pituitary insufficiency. Caution in renal or hepatic impairment; dose adjustment/alternative may be needed. Stop and seek care for severe allergy, jaundice, persistent abdominal pain, or signs of severe low sugar. Not indicated for type 1 diabetes or diabetic ketoacidosis. Inform doctor before surgery/acute illness as treatment may need adjustment.

Other antidiabetics (insulin, metformin) and alcohol may increase hypoglycaemia risk; beta-blockers may mask hypoglycaemia symptoms; azole antifungals (e.g., miconazole/fluconazole), macrolides, sulfonamides and some quinolones can increase effect; corticosteroids, thiazide diuretics, sympathomimetics may raise glucose and reduce efficacy; warfarin effect may be increased—monitor INR.

Store below 25°C, protected from moisture and light. Keep in original strip/container and out of reach of children.

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