Sazo 500 Tablet

Sazo 500 Tablet contains Sulfasalazine (500mg). Prescription required.

Treatment of ulcerative colitis (acute flares and maintenance), Crohn’s colitis (adjunct/selected cases), rheumatoid arthritis (DMARD) including juvenile idiopathic arthritis (as prescribed).

Sulfasalazine is converted in the colon to 5-aminosalicylic acid and sulfapyridine. It reduces intestinal inflammation in inflammatory bowel disease and also modulates immune/inflammatory pathways to reduce joint inflammation in rheumatoid arthritis.

Tablet for oral use. Take exactly as prescribed, preferably after food with a full glass of water. Swallow whole (do not crush/chew) and maintain good hydration; dosing is usually started low and increased gradually to reduce stomach upset.

Nausea, vomiting, abdominal pain, loss of appetite, headache, dizziness, rash, fever, reversible low sperm count, orange/yellow discoloration of urine/skin, elevated liver enzymes

Use only on prescription. Inform doctor if you have allergy to sulfonamides or salicylates, G6PD deficiency, liver or kidney disease, asthma, blood disorders, or intestinal/urinary obstruction. Can cause serious skin reactions (SJS/TEN), blood dyscrasias (low WBC/platelets), hepatotoxicity, and worsening of ulcerative colitis in rare cases—seek urgent care for rash, mouth ulcers, fever, sore throat, unusual bruising/bleeding, yellowing of eyes/skin. Regular monitoring of CBC and liver function is advised. May reduce folate levels—supplementation may be recommended. Avoid excessive sun exposure if photosensitivity occurs.

Methotrexate (increased toxicity risk), azathioprine/6-mercaptopurine (myelosuppression risk), warfarin (may alter anticoagulant effect), digoxin (reduced absorption), oral antidiabetic medicines (enhanced hypoglycaemia risk), sulfonylureas, phenytoin (altered levels), folic acid (reduced absorption), certain antibiotics that alter gut flora (may change effect).

Store below 25°C in a dry place, protected from moisture and light. Keep in original blister pack and out of reach of children.

Salazopyrin 500 Tablet, Sulfasalazine 500 mg Tablet (generic), Saaz 500 Tablet, Sazo 500 Tablet (other pack), Sulfa 500 Tablet (sulfasalazine)