Tapdol 50MG ER Tab

Tablet

Management of moderate to severe chronic pain requiring around-the-clock opioid analgesic treatment when alternative treatments are inadequate

Tapentadol is a centrally acting analgesic with dual action: it is a mu-opioid receptor agonist and also inhibits norepinephrine reuptake. These actions reduce pain signal transmission and perception in the brain and spinal cord.

Oral extended-release tablet. Swallow whole with water; do not crush, chew, or split. Take exactly as prescribed at the same times each day; may be taken with or without food. Do not stop suddenly without medical advice.

Nausea, vomiting, constipation, dizziness, drowsiness, headache, dry mouth, sweating, fatigue

Opioid medicine: risk of addiction, abuse and misuse; can cause life-threatening respiratory depression, especially at initiation or dose increase. Avoid use with alcohol or other CNS depressants (sedatives, sleeping pills) due to excessive sedation/respiratory depression. Use with caution in elderly, liver or kidney impairment, head injury, seizure disorders, low blood pressure, respiratory disease (e.g., COPD, sleep apnea). May cause drowsiness—avoid driving/operating machinery. Risk of serotonin syndrome when combined with serotonergic drugs. Not for acute pain or as-needed use in ER form; keep out of reach of children.

Alcohol, benzodiazepines and other sedatives/CNS depressants, other opioids, MAO inhibitors (contraindicated/avoid), SSRIs/SNRIs/TCAs/triptans/linezolid (serotonin syndrome risk), antipsychotics, gabapentinoids, strong CYP enzyme inducers/inhibitors may alter effects (clinical monitoring advised)

Store below 25°C in a cool, dry place away from light and moisture. Keep in original pack and out of reach of children.

Tapentadol ER 50 mg tablets (other brands), Tydol ER 50 Tablet, Tapal ER 50 Tablet, Tapenta ER 50 Tablet, Tapen ER 50 Tablet