Drug | Tablet

Depression; neuropathic (nerve) pain; prevention of migraine/tension-type headache (as prescribed); certain anxiety/sleep disorders (off-label, doctor-directed)

Amitriptyline is a tricyclic antidepressant that increases levels of serotonin and noradrenaline in the brain by inhibiting their reuptake, improving mood. It also modulates pain pathways and has sedative effects, which can help in neuropathic pain and sleep.

Take exactly as prescribed. Usually taken by mouth once daily, preferably at bedtime due to drowsiness; can be taken with or without food. Swallow whole with water. Do not stop suddenly—dose is usually tapered by the doctor.

Drowsiness, dizziness, dry mouth, constipation, blurred vision, weight gain, increased appetite, nausea, difficulty urinating, sweating, fast heartbeat, low blood pressure on standing

May cause marked drowsiness—avoid driving/operating machinery until effects are known. Risk of suicidal thoughts/behavior especially at start of therapy or dose changes; monitor closely. Avoid in recent heart attack; use caution in heart disease, arrhythmias, glaucoma (narrow-angle), urinary retention/prostate enlargement, seizures, bipolar disorder/mania, liver disease, and elderly (higher anticholinergic effects/fall risk). Do not use with MAO inhibitors (or within 14 days). Serotonin syndrome risk with serotonergic medicines. Do not stop abruptly (withdrawal symptoms).

MAO inhibitors (contraindicated), other antidepressants/SSRIs/SNRIs (e.g., fluoxetine, sertraline) and triptans (serotonin syndrome risk), alcohol/CNS depressants (increased sedation), anticholinergics (increased side effects), QT-prolonging drugs (e.g., certain antiarrhythmics/antipsychotics/macrolides), antihypertensives (additive hypotension), cimetidine (increases levels), carbamazepine/phenytoin (may reduce levels), tramadol (seizure/serotonin syndrome risk), warfarin (may alter anticoagulant effect)

Store at room temperature (below 25°C), protected from light and moisture. Keep in original pack and out of reach of children.

Amitone 75 Tablet, Elavil 75 Tablet, Amitriptyline 75 mg Tablet (generic), Triptizol 75 Tablet, Saroten 75 Tablet