Drug | Tablet

Treatment of type 2 diabetes mellitus in adults to improve blood glucose control when diet and exercise alone or single therapy is insufficient.

Glimepiride (a sulfonylurea) increases insulin release from pancreatic beta cells and improves peripheral glucose utilization. Metformin SR (a biguanide) reduces hepatic glucose production and improves insulin sensitivity, helping lower fasting and post‑meal blood sugar.

Take by mouth exactly as prescribed, usually once daily with breakfast or the first main meal. Swallow tablet whole (do not crush/chew due to sustained release). Monitor blood glucose regularly; follow diet and exercise advice.

Nausea, vomiting, diarrhea, abdominal pain, loss of appetite, metallic taste, headache, dizziness, hypoglycemia (sweating, tremor, palpitations), weight gain

Risk of hypoglycemia (higher with missed meals, alcohol, intense exercise, elderly); carry fast-acting glucose. Metformin can rarely cause lactic acidosis—seek urgent care for rapid breathing, severe weakness, abdominal pain, hypothermia. Avoid/use with caution in kidney impairment; periodic renal function tests needed. Use caution in liver disease, heart failure, dehydration, severe infection, or hypoxia. Temporarily stop before/after iodinated contrast procedures and major surgery as advised by doctor.

Alcohol (increases hypoglycemia/lactic acidosis risk), insulin/other antidiabetics (additive hypoglycemia), beta-blockers (mask hypoglycemia symptoms), corticosteroids/diuretics (raise glucose), ACE inhibitors (may enhance glucose-lowering), fluoroquinolones (dysglycemia), rifampicin (may reduce effect), cimetidine (may increase metformin levels), iodinated contrast media (risk of kidney injury/lactic acidosis)

Store below 25°C in a dry place, protected from moisture and light. Keep in original blister pack and out of reach of children.

Amaryl M 1 Tablet, Glimy M 1 Tablet, Glycomet-GP 1 Tablet, Glimiprex M 1 Tablet, Glynase MF 1 Tablet