Distributor inventory

Treatment of diabetes mellitus to improve glycaemic control in adults; also used in children/adolescents as per clinician advice depending on approved local labeling. Used as long-acting (basal) insulin in type 1 diabetes (with mealtime insulin) and type 2 diabetes.

Insulin glargine is a long-acting basal insulin analog. After subcutaneous injection it forms microprecipitates that slowly release insulin, providing a steady glucose-lowering effect over ~24 hours or longer by increasing peripheral glucose uptake and reducing hepatic glucose production.

For subcutaneous injection only using the Toujeo pen. Inject once daily at the same time each day into abdomen, thigh, or upper arm; rotate injection sites. Use as directed by a doctor; do not share pen/needles. Do not dilute or mix with other insulins; not for IV use.

Hypoglycaemia, injection site reactions (pain/redness/swelling/itching), weight gain, lipodystrophy (lipoatrophy/lipohypertrophy), edema, rash, allergic reactions

Risk of severe hypoglycaemia—monitor blood glucose and adjust dose with changes in diet, exercise, illness, or other medicines. Not for treatment of diabetic ketoacidosis (use rapid-acting insulin/IV insulin). Do not use in insulin pumps or intravenously. Use caution in renal/hepatic impairment and in elderly; dose adjustments may be needed. Rotate injection sites to reduce lipodystrophy. Seek urgent care for severe allergy, breathing difficulty, or persistent low sugars.

Other antidiabetic drugs (additive hypoglycaemia), sulfonylureas/meglitinides (increased hypoglycaemia), beta-blockers (may mask hypoglycaemia symptoms), ACE inhibitors (may increase hypoglycaemia risk), corticosteroids/thyroid hormones/sympathomimetics/diuretics (may raise glucose and increase insulin requirements), alcohol (may increase hypoglycaemia risk), thiazolidinediones (pioglitazone/rosiglitazone—risk of fluid retention/heart failure with insulin)

Unopened: refrigerate 2–8°C; do not freeze; protect from light. In-use pen: keep below 25–30°C (per pack insert), away from heat/light; do not refrigerate once in use; discard after the in-use period stated on pack (commonly up to 42 days). Keep cap on when not in use.

Lantus SoloStar 100 IU/mL (insulin glargine), Basaglar KwikPen 100 IU/mL (insulin glargine), Tresiba FlexTouch (insulin degludec), Levemir FlexPen (insulin detemir), Insulatard Penfill/FlexPen (NPH insulin)