Zoryl M 4 Forte

Glimepiride (1mg) + Metformin (1000mg)

Type 2 diabetes mellitus (in adults) when blood sugar is not adequately controlled with diet, exercise and single-drug therapy; helps control fasting and post-meal glucose

Glimepiride (a sulfonylurea) increases insulin release from the pancreas and improves insulin action in the body. Metformin SR (a biguanide) reduces glucose production by the liver and improves insulin sensitivity, lowering blood glucose without usually causing weight gain.

Take orally exactly as prescribed, usually once daily with food (preferably with breakfast/main meal). Swallow the sustained-release tablet whole; do not crush or chew. Follow diet/exercise plan and monitor blood glucose regularly.

Nausea, diarrhoea, abdominal pain, metallic taste, headache, dizziness, hypoglycaemia, weight gain

Risk of hypoglycaemia (more likely with missed meals, excess exercise, alcohol, or with other antidiabetics); carry glucose source. Metformin may rarely cause lactic acidosis—risk increases with severe kidney impairment, dehydration, sepsis, hypoxia, or excess alcohol; kidney function monitoring is required. Use caution in liver disease, elderly, malnourished, and during acute illness/surgery. Withhold metformin before/at iodinated contrast studies and restart only after renal function is stable as advised by doctor.

Alcohol (increases risk of hypoglycaemia and lactic acidosis), insulin/other antidiabetics (additive hypoglycaemia), beta-blockers (mask hypoglycaemia), corticosteroids/thiazide diuretics/sympathomimetics (raise glucose), ACE inhibitors (may increase hypoglycaemia), NSAIDs and sulfonamides (may increase hypoglycaemia), rifampicin (reduces glimepiride effect), azole antifungals and macrolides (may increase glimepiride effect), iodinated contrast media (lactic acidosis risk with metformin)

Store below 25°C in a dry place, protected from light and moisture. Keep out of reach of children.

Glimy M 4 Forte Tablet, Glimistar M 4 Forte Tablet, Amaryl M Forte 4 Tablet, Glycomet-GP 4 Forte Tablet, Gluconorm-G 4 Forte Tablet