Prescription requiredAntidiabetic

Amaryl M 2 Tablet — Side Effects & Warnings

Known side effects of Amaryl M 2 Tablet include Hypoglycaemia (low blood sugar), nausea, diarrhoea, abdominal pain, vomiting, headache, dizziness, metallic taste, weight gain. Not everyone experiences these side effects.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated July 2026

Common Side Effects

Hypoglycaemia (low blood sugar)
nausea
diarrhoea
abdominal pain
vomiting
headache
dizziness
metallic taste
weight gain

This is not an exhaustive list. Consult your doctor if you notice any unusual symptoms.

Important Warnings

Risk of hypoglycaemia (especially with missed meals, strenuous exercise, or alcohol); carry sugar/glucose. Metformin can rarely cause lactic acidosis—risk increases in kidney or liver disease, severe infection, dehydration, heavy alcohol use, or low oxygen states; avoid in severe renal impairment and temporarily stop during severe illness. Inform doctor before surgery or iodinated contrast scans (may need to stop metformin). Monitor kidney function and vitamin B12 with long-term use. Use caution in elderly and those with irregular eating habits.

Drug Interactions

Amaryl M 2 Tablet may interact with the following:

Alcohol (increases hypoglycaemia/lactic acidosis risk)
insulin/other antidiabetics (additive hypoglycaemia)
beta-blockers (mask hypoglycaemia symptoms)
corticosteroids and thiazide diuretics (raise blood sugar)
ACE inhibitors (may increase hypoglycaemia)
rifampicin (reduces effect)
azole antifungals/clarithromycin (increase hypoglycaemia risk)
iodinated contrast media (lactic acidosis risk with metformin)
cimetidine (increases metformin levels)

Always tell your doctor about all medicines you are taking, including over-the-counter drugs and supplements.

Pregnancy Safety

Consult doctor (not recommended; insulin is generally preferred in pregnancy)

Alcohol Interaction

Avoid

Habit Forming

Storage

Store below 25°C in a dry place, protected from light and moisture. Keep out of reach of children.

Amaryl M 2 Tablet — Safety Summary

Composition: Glimepiride 2 mg + Metformin (sustained release) 500 mg
Prescription: Required (Rx)
Pregnancy: Consult doctor (not recommended; insulin is generally preferred in pregnancy)
Alcohol: Avoid
Habit forming: No

Amaryl M 2 Tablet — Safety FAQs

What should I do if I experience side effects?

Mild side effects often resolve on their own. If side effects are severe or persistent, stop the medicine and consult your doctor immediately.

Are all listed side effects common?

No. Some side effects are common while others are rare. Not everyone experiences side effects. Consult your doctor if you are concerned.

Can I take this medicine with other drugs?

Some medicines interact with each other. Always inform your doctor about all medicines you are currently taking.

When should I seek emergency help?

Seek immediate medical attention if you experience severe allergic reactions (difficulty breathing, swelling of face/throat), chest pain, or any life-threatening symptoms.

Get help from a doctor

Consult a doctor

Discuss side effects with a qualified doctor online.

View all medicines

Full product details for Amaryl M 2 Tablet.

Lab tests

Book tests to monitor your health while on medication.

Sick leave certificate

Unwell and need rest? A doctor can issue a leave certificate online, from ₹499.

Safety disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice. If you experience severe side effects, seek medical attention immediately.