Prescription requiredAntidiabetic

Glycomet Trio 1MG Tab — Side Effects & Warnings

Known side effects of Glycomet Trio 1MG Tab include Hypoglycaemia, nausea, vomiting, diarrhoea, abdominal pain, loss of appetite, headache, dizziness, weight gain, peripheral oedema (swelling), upper respiratory tract infection. Not everyone experiences these side effects.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated June 2026

Common Side Effects

Hypoglycaemia
nausea
vomiting
diarrhoea
abdominal pain
loss of appetite
headache
dizziness
weight gain
peripheral oedema (swelling)
upper respiratory tract infection

This is not an exhaustive list. Consult your doctor if you notice any unusual symptoms.

Important Warnings

Risk of hypoglycaemia (higher with missed meals, alcohol, heavy exercise); metformin may rarely cause lactic acidosis—seek urgent care for fast breathing, severe weakness, abdominal pain, or unusual sleepiness; avoid/use with caution in severe kidney impairment and monitor renal function; pioglitazone can cause fluid retention and may worsen heart failure—contraindicated in NYHA III/IV heart failure; monitor for weight gain/ankle swelling; possible increased fracture risk and macular oedema with pioglitazone; use with caution in liver disease—check LFTs; temporarily stop metformin before/after iodinated contrast or major surgery as advised by doctor.

Drug Interactions

Glycomet Trio 1MG Tab may interact with the following:

Alcohol (increases hypoglycaemia and lactic acidosis risk)
insulin/other antidiabetics (additive hypoglycaemia)
beta-blockers (mask hypoglycaemia symptoms)
corticosteroids and thiazide/loop diuretics (raise glucose)
rifampicin (reduces pioglitazone levels)
gemfibrozil (increases pioglitazone levels)
cimetidine (may increase metformin levels)
iodinated contrast media (kidney injury/lactic acidosis risk)
ACE inhibitors/ARBs (may enhance glucose-lowering)

Always tell your doctor about all medicines you are taking, including over-the-counter drugs and supplements.

Pregnancy Safety

Not recommended; consult doctor (prefer insulin in pregnancy)

Alcohol Interaction

Avoid

Habit Forming

Storage

Store below 25°C in a cool, dry place. Protect from moisture and direct light. Keep in original blister pack and out of reach of children.

Glycomet Trio 1MG Tab — Safety Summary

Composition: Glimepiride (1mg) + Metformin (500mg) + Voglibose (0.3mg)
Prescription: Required (Rx)
Pregnancy: Not recommended; consult doctor (prefer insulin in pregnancy)
Alcohol: Avoid
Habit forming: No

Glycomet Trio 1MG Tab — Safety FAQs

What should I do if I experience side effects?

Mild side effects often resolve on their own. If side effects are severe or persistent, stop the medicine and consult your doctor immediately.

Are all listed side effects common?

No. Some side effects are common while others are rare. Not everyone experiences side effects. Consult your doctor if you are concerned.

Can I take this medicine with other drugs?

Some medicines interact with each other. Always inform your doctor about all medicines you are currently taking.

When should I seek emergency help?

Seek immediate medical attention if you experience severe allergic reactions (difficulty breathing, swelling of face/throat), chest pain, or any life-threatening symptoms.

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Safety disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice. If you experience severe side effects, seek medical attention immediately.

Glycomet Trio 1MG Tab — Side Effects & Warnings

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated June 2026