Prescription requiredAnalgesic / Anti-inflammatory (NSAID)

Naprosyn + 250MG — Side Effects & Warnings

Known side effects of Naprosyn + 250MG include Acidity/heartburn, nausea, vomiting, stomach pain, indigestion, diarrhoea, dizziness, headache, drowsiness, fluid retention/edema, rash. Not everyone experiences these side effects.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated June 2026

Common Side Effects

Acidity/heartburn
nausea
vomiting
stomach pain
indigestion
diarrhoea
dizziness
headache
drowsiness
fluid retention/edema
rash

This is not an exhaustive list. Consult your doctor if you notice any unusual symptoms.

Important Warnings

May cause stomach/intestinal ulceration, bleeding or perforation—risk higher in elderly, history of ulcer, with alcohol, steroids or blood thinners. Use with caution in kidney disease, liver disease, asthma/NSAID allergy, hypertension, heart failure, and cardiovascular disease; can increase risk of heart attack or stroke with prolonged/high-dose use. Stop and seek care if black stools, blood vomiting, severe abdominal pain, chest pain, breathing trouble, facial swelling or severe rash occur. Avoid use around coronary artery bypass graft (CABG) surgery. Not recommended in late pregnancy (third trimester) due to risk to the fetus; may affect fertility in some women.

Drug Interactions

Naprosyn + 250MG may interact with the following:

Anticoagulants/antiplatelets (warfarin
apixaban
rivaroxaban
clopidogrel)
other NSAIDs/aspirin
corticosteroids
SSRIs/SNRIs
ACE inhibitors/ARBs (enalapril
losartan) and diuretics (furosemide) (kidney risk)
lithium
methotrexate
cyclosporine/tacrolimus
digoxin

Always tell your doctor about all medicines you are taking, including over-the-counter drugs and supplements.

Pregnancy Safety

Use with caution (avoid in 3rd trimester; consult doctor)

Alcohol Interaction

Avoid (increases risk of stomach bleeding and irritation)

Habit Forming

Storage

Store at room temperature (below 25°C), protected from moisture and direct light. Keep in original strip and out of reach of children.

Naprosyn + 250MG — Safety Summary

Composition: Naproxen 250 mg (as Naproxen) tablet
Prescription: Required (Rx)
Pregnancy: Use with caution (avoid in 3rd trimester; consult doctor)
Alcohol: Avoid (increases risk of stomach bleeding and irritation)
Habit forming: No

Naprosyn + 250MG — Safety FAQs

What should I do if I experience side effects?

Mild side effects often resolve on their own. If side effects are severe or persistent, stop the medicine and consult your doctor immediately.

Are all listed side effects common?

No. Some side effects are common while others are rare. Not everyone experiences side effects. Consult your doctor if you are concerned.

Can I take this medicine with other drugs?

Some medicines interact with each other. Always inform your doctor about all medicines you are currently taking.

When should I seek emergency help?

Seek immediate medical attention if you experience severe allergic reactions (difficulty breathing, swelling of face/throat), chest pain, or any life-threatening symptoms.

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Safety disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice. If you experience severe side effects, seek medical attention immediately.