Prescription requiredAntipsychotic

Paliris La 50MG Pfs — Side Effects & Warnings

Known side effects of Paliris La 50MG Pfs include Injection site pain, sleepiness/sedation, dizziness, headache, weight gain, increased prolactin (breast changes/menstrual changes), restlessness/akathisia, tremor/extrapyramidal symptoms, constipation.... Not everyone experiences these side effects.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated June 2026

Common Side Effects

Injection site pain
sleepiness/sedation
dizziness
headache
weight gain
increased prolactin (breast changes/menstrual changes)
restlessness/akathisia
tremor/extrapyramidal symptoms
constipation
dry mouth
nausea

This is not an exhaustive list. Consult your doctor if you notice any unusual symptoms.

Important Warnings

Use only under specialist supervision. May cause drowsiness and dizziness—avoid driving until you know the effect. Risk of extrapyramidal symptoms/tardive dyskinesia, neuroleptic malignant syndrome, increased prolactin, weight gain and metabolic changes (blood sugar/lipids), orthostatic hypotension, seizures, QT prolongation/heart rhythm problems. Increased risk of stroke and death in elderly patients with dementia-related psychosis (not approved). Use caution in diabetes, obesity, Parkinsonism, epilepsy, cardiovascular disease, and in patients with history of blood clots. Monitor weight, glucose, lipids, and movement disorders as advised.

Drug Interactions

Paliris La 50MG Pfs may interact with the following:

Alcohol and other CNS depressants (increased sedation)
medicines that prolong QT (e.g.
amiodarone
sotalol
certain macrolides/fluoroquinolones
some antidepressants/antipsychotics)
antihypertensives (additive low BP)
dopamine agonists (e.g.
levodopa
bromocriptine) may reduce effect
strong CYP inducers (e.g.
carbamazepine
rifampicin) may reduce paliperidone exposure
valproate may increase paliperidone levels

Always tell your doctor about all medicines you are taking, including over-the-counter drugs and supplements.

Pregnancy Safety

Use with caution / Consult doctor (use only if benefits outweigh risks; newborn may have withdrawal/EPS if exposed late in pregnancy)

Alcohol Interaction

Avoid

Habit Forming

Storage

Store refrigerated at 2–8°C; do not freeze. Keep in original pack protected from light. Do not use if suspension shows clumping that does not disperse on gentle shaking as per leaflet; keep out of reach of children.

Paliris La 50MG Pfs — Safety Summary

Composition: Paliperidone palmitate 50 mg/0.5 mL (long-acting injectable suspension)
Prescription: Required (Rx)
Pregnancy: Use with caution / Consult doctor (use only if benefits outweigh risks; newborn may have withdrawal/EPS if exposed late in pregnancy)
Alcohol: Avoid
Habit forming: No

Paliris La 50MG Pfs — Safety FAQs

What should I do if I experience side effects?

Mild side effects often resolve on their own. If side effects are severe or persistent, stop the medicine and consult your doctor immediately.

Are all listed side effects common?

No. Some side effects are common while others are rare. Not everyone experiences side effects. Consult your doctor if you are concerned.

Can I take this medicine with other drugs?

Some medicines interact with each other. Always inform your doctor about all medicines you are currently taking.

When should I seek emergency help?

Seek immediate medical attention if you experience severe allergic reactions (difficulty breathing, swelling of face/throat), chest pain, or any life-threatening symptoms.

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Safety disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice. If you experience severe side effects, seek medical attention immediately.

Paliris La 50MG Pfs — Side Effects & Warnings

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated June 2026