Prescription requiredAntidepressant

Prothiaden 25 Tablet — Side Effects & Warnings

Known side effects of Prothiaden 25 Tablet include Drowsiness/sedation, dry mouth, constipation, blurred vision, dizziness, weight gain, nausea, sweating, tremor, palpitations, postural hypotension. Not everyone experiences these side effects.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated July 2026

Common Side Effects

Drowsiness/sedation
dry mouth
constipation
blurred vision
dizziness
weight gain
nausea
sweating
tremor
palpitations
postural hypotension

This is not an exhaustive list. Consult your doctor if you notice any unusual symptoms.

Important Warnings

Prescription Schedule H medicine. May cause drowsiness—avoid driving/operating machinery until you know the effect. Risk of suicidal thoughts/behaviour particularly in young adults at start or dose changes—seek urgent help if worsening mood or self-harm thoughts occur. Use with caution in heart disease, arrhythmias, recent myocardial infarction, epilepsy, liver impairment, glaucoma, urinary retention/prostatic hypertrophy, and elderly (falls/confusion). Do not use with MAO inhibitors or within 14 days of stopping them. Taper gradually to avoid withdrawal symptoms.

Drug Interactions

Prothiaden 25 Tablet may interact with the following:

MAO inhibitors (contraindicated)
alcohol and other CNS depressants (increased sedation)
other antidepressants/serotonergic drugs (risk of serotonin syndrome)
QT-prolonging drugs (arrhythmia risk)
antiarrhythmics
anticholinergics
antihypertensives (additive hypotension)
cimetidine (may increase levels)
enzyme inducers like carbamazepine/phenytoin (may reduce levels)
tramadol (seizure/serotonin risk)

Always tell your doctor about all medicines you are taking, including over-the-counter drugs and supplements.

Pregnancy Safety

Use with caution / Consult doctor

Alcohol Interaction

Avoid

Habit Forming

Storage

Store below 25°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.

Prothiaden 25 Tablet — Safety Summary

Composition: Dosulepin (Dothiepin) Hydrochloride 25 mg
Prescription: Required (Rx)
Pregnancy: Use with caution / Consult doctor
Alcohol: Avoid
Habit forming: No

Prothiaden 25 Tablet — Safety FAQs

What should I do if I experience side effects?

Mild side effects often resolve on their own. If side effects are severe or persistent, stop the medicine and consult your doctor immediately.

Are all listed side effects common?

No. Some side effects are common while others are rare. Not everyone experiences side effects. Consult your doctor if you are concerned.

Can I take this medicine with other drugs?

Some medicines interact with each other. Always inform your doctor about all medicines you are currently taking.

When should I seek emergency help?

Seek immediate medical attention if you experience severe allergic reactions (difficulty breathing, swelling of face/throat), chest pain, or any life-threatening symptoms.

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Safety disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice. If you experience severe side effects, seek medical attention immediately.

Prothiaden 25 Tablet — Side Effects & Warnings

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated July 2026