Prescription requiredAntidiabetic (Insulin)

Toujeo 450 IU — Side Effects & Warnings

Known side effects of Toujeo 450 IU include Hypoglycaemia, injection site reactions (pain/redness/swelling/itching), weight gain, lipodystrophy (lipoatrophy/lipohypertrophy), edema, rash, allergic reactions. Not everyone experiences these side effects.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated June 2026

Common Side Effects

Hypoglycaemia
injection site reactions (pain/redness/swelling/itching)
weight gain
lipodystrophy (lipoatrophy/lipohypertrophy)
edema
rash
allergic reactions

This is not an exhaustive list. Consult your doctor if you notice any unusual symptoms.

Important Warnings

Risk of severe hypoglycaemia—monitor blood glucose and adjust dose with changes in diet, exercise, illness, or other medicines. Not for treatment of diabetic ketoacidosis (use rapid-acting insulin/IV insulin). Do not use in insulin pumps or intravenously. Use caution in renal/hepatic impairment and in elderly; dose adjustments may be needed. Rotate injection sites to reduce lipodystrophy. Seek urgent care for severe allergy, breathing difficulty, or persistent low sugars.

Drug Interactions

Toujeo 450 IU may interact with the following:

Other antidiabetic drugs (additive hypoglycaemia)
sulfonylureas/meglitinides (increased hypoglycaemia)
beta-blockers (may mask hypoglycaemia symptoms)
ACE inhibitors (may increase hypoglycaemia risk)
corticosteroids/thyroid hormones/sympathomimetics/diuretics (may raise glucose and increase insulin requirements)
alcohol (may increase hypoglycaemia risk)
thiazolidinediones (pioglitazone/rosiglitazone—risk of fluid retention/heart failure with insulin)

Always tell your doctor about all medicines you are taking, including over-the-counter drugs and supplements.

Pregnancy Safety

Consult doctor (insulin is commonly used in pregnancy; dose adjustment and close monitoring required)

Alcohol Interaction

Use with caution (may increase risk of hypoglycaemia)

Habit Forming

Storage

Unopened: refrigerate 2–8°C; do not freeze; protect from light. In-use pen: keep below 25–30°C (per pack insert), away from heat/light; do not refrigerate once in use; discard after the in-use period stated on pack (commonly up to 42 days). Keep cap on when not in use.

Toujeo 450 IU — Safety Summary

Composition: Insulin glargine 450 IU/3 mL (U-300; 300 units/mL) solution for injection in prefilled pen (Toujeo SoloStar)
Prescription: Required (Rx)
Pregnancy: Consult doctor (insulin is commonly used in pregnancy; dose adjustment and close monitoring required)
Alcohol: Use with caution (may increase risk of hypoglycaemia)
Habit forming: No

Toujeo 450 IU — Safety FAQs

What should I do if I experience side effects?

Mild side effects often resolve on their own. If side effects are severe or persistent, stop the medicine and consult your doctor immediately.

Are all listed side effects common?

No. Some side effects are common while others are rare. Not everyone experiences side effects. Consult your doctor if you are concerned.

Can I take this medicine with other drugs?

Some medicines interact with each other. Always inform your doctor about all medicines you are currently taking.

When should I seek emergency help?

Seek immediate medical attention if you experience severe allergic reactions (difficulty breathing, swelling of face/throat), chest pain, or any life-threatening symptoms.

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Safety disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice. If you experience severe side effects, seek medical attention immediately.

Toujeo 450 IU — Side Effects & Warnings

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated June 2026