Prescription requiredAntidiabetic

Trajenta Duo 2.5/1000 Tablet — Side Effects & Warnings

Known side effects of Trajenta Duo 2.5/1000 Tablet include Nausea, vomiting, diarrhoea, abdominal pain, loss of appetite, metallic taste, headache, nasopharyngitis, cough, dizziness, hypoglycaemia (more likely with insulin/sulfonylureas), vitamin B12 deficien.... Not everyone experiences these side effects.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated July 2026

Common Side Effects

Nausea
vomiting
diarrhoea
abdominal pain
loss of appetite
metallic taste
headache
nasopharyngitis
cough
dizziness
hypoglycaemia (more likely with insulin/sulfonylureas)
vitamin B12 deficiency (long-term)

This is not an exhaustive list. Consult your doctor if you notice any unusual symptoms.

Important Warnings

Risk of lactic acidosis with metformin (rare but serious): higher risk in kidney impairment, dehydration, severe infection, shock, liver disease, heavy alcohol use, or hypoxia/heart failure—seek urgent care for fast breathing, severe weakness, abdominal pain, or drowsiness. Assess renal function before starting and periodically; dose adjustments/avoid in significant renal impairment as per prescribing info. Temporarily stop metformin around iodinated contrast procedures and major surgery as advised. Pancreatitis and severe joint pain have been reported with DPP-4 inhibitors—stop and consult doctor if severe abdominal pain occurs. Use caution in elderly, undernourished, or those with alcohol use; monitor B12 with long-term use.

Drug Interactions

Trajenta Duo 2.5/1000 Tablet may interact with the following:

Iodinated contrast media
alcohol
carbonic anhydrase inhibitors (e.g.
topiramate
acetazolamide)
cimetidine (may increase metformin levels)
rifampicin (may reduce linagliptin effect)
strong P-gp/CYP3A4 inducers (e.g.
carbamazepine
phenytoin
phenobarbital
rifampicin
St John’s wort)
insulin and sulfonylureas (increased hypoglycaemia risk)

Always tell your doctor about all medicines you are taking, including over-the-counter drugs and supplements.

Pregnancy Safety

Consult doctor (not recommended unless clearly needed; insulin is generally preferred for diabetes in pregnancy)

Alcohol Interaction

Avoid (increases risk of lactic acidosis and hypoglycaemia)

Habit Forming

Storage

Store below 25°C in a dry place, protected from moisture and light. Keep in original blister pack and out of reach of children.

Trajenta Duo 2.5/1000 Tablet — Safety Summary

Composition: Linagliptin 2.5 mg + Metformin hydrochloride 1000 mg (prolonged/extended-release may vary by pack; confirm pack label)
Prescription: Required (Rx)
Pregnancy: Consult doctor (not recommended unless clearly needed; insulin is generally preferred for diabetes in pregnancy)
Alcohol: Avoid (increases risk of lactic acidosis and hypoglycaemia)
Habit forming: No

Trajenta Duo 2.5/1000 Tablet — Safety FAQs

What should I do if I experience side effects?

Mild side effects often resolve on their own. If side effects are severe or persistent, stop the medicine and consult your doctor immediately.

Are all listed side effects common?

No. Some side effects are common while others are rare. Not everyone experiences side effects. Consult your doctor if you are concerned.

Can I take this medicine with other drugs?

Some medicines interact with each other. Always inform your doctor about all medicines you are currently taking.

When should I seek emergency help?

Seek immediate medical attention if you experience severe allergic reactions (difficulty breathing, swelling of face/throat), chest pain, or any life-threatening symptoms.

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Safety disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice. If you experience severe side effects, seek medical attention immediately.

Trajenta Duo 2.5/1000 Tablet — Side Effects & Warnings

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated July 2026