Triopil 1 Tablet

Composition of Triopil 1 Tablet

Triopil 1 Tablet contains Glimepiride (1mg) + Metformin (500mg) + Pioglitazone (15mg). It belongs to the Sulfonylurea + Biguanide + Thiazolidinedione (TZD) class of medicines.

Uses of Triopil 1 Tablet

Type 2 diabetes mellitus (adult) to improve blood sugar control when diet and exercise alone or fewer medicines are not adequate

Key benefits

• Lowers fasting and post-meal blood sugar
• Improves insulin sensitivity
• Helps achieve better HbA1c control than dual therapy
• Convenient triple-therapy in one tablet

How Triopil 1 Tablet works

Glimepiride (a sulfonylurea) increases insulin release from the pancreas. Metformin reduces glucose production in the liver and improves insulin sensitivity. Pioglitazone improves insulin sensitivity in muscle and fat by activating PPAR-γ, helping the body use insulin better.

How to take Triopil 1 Tablet

Take exactly as prescribed by your doctor. Usually taken once daily with/after food (preferably with breakfast) to reduce stomach upset; swallow tablet whole (do not crush/chew, especially if sustained/extended-release). Monitor blood glucose regularly.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

If you miss a dose of Triopil 1 Tablet SR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

If you take too much

An overdose of this medicine can cause severe and prolonged low blood sugar, which may lead to fits or unconsciousness. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. It may cause low blood sugar and marked stomach upset. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Triopil 1 Tablet

Most side effects of Triopil are mild and settle as the body adjusts. Reported side effects include:

• Hypoglycaemia
• nausea
• vomiting
• diarrhoea
• abdominal pain
• loss of appetite
• headache
• dizziness
• weight gain
• fluid retention/edema

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Triopil 1 Tablet

Warnings and precautions

May cause low blood sugar—risk increases with missed meals, alcohol, excess exercise, or with other antidiabetics; keep glucose/sugar source available. Metformin can rarely cause lactic acidosis—risk higher in kidney disease, dehydration, severe infection, heavy alcohol use; dose adjustment/avoid in renal impairment. Pioglitazone may cause fluid retention and can worsen heart failure; avoid/use with caution in heart failure and monitor for swelling/shortness of breath. Periodic monitoring of blood sugar, kidney function, liver function and weight is advised. Inform doctor before surgery or contrast dye procedures (metformin may need temporary stoppage).

Do not take Triopil if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney or liver disease. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis. Not for people with heart failure, active bladder cancer or unexplained blood in the urine.

Interactions with other medicines

Alcohol (increases risk of hypoglycaemia and lactic acidosis), insulin/other antidiabetics (increased hypoglycaemia), diuretics and steroids (may raise blood sugar), rifampicin (may reduce pioglitazone effect), gemfibrozil (may increase pioglitazone levels), iodinated contrast media (risk of metformin-associated lactic acidosis), beta-blockers (may mask hypoglycaemia symptoms)

How to store Triopil 1 Tablet

Store below 25°C in a cool, dry place away from moisture and direct light. Keep in original strip and out of reach of children.

Expert advice for Triopil 1 Tablet

Take it with food to lower your chance of having an upset stomach. It may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal. Always carry some sugary food or fruit juice with you in case you experience hypoglycemic symptoms such as cold sweats, cool pale skin, tremor, and anxiety. Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).

Manufacturer and class

Manufacturer:

ARISTO PHARMACEUTICALS PVT LTD

Therapeutic class:

Antidiabetic

Drug class:

Sulfonylurea + Biguanide + Thiazolidinedione (TZD)