Prescription requiredHypnotic/Sedative (Sleep aid)

Zolpirest 5 — Side Effects & Warnings

Known side effects of Zolpirest 5 include drowsiness, dizziness, headache, nausea, diarrhoea, dry mouth, fatigue, next-day sleepiness. Not everyone experiences these side effects.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated June 2026

Common Side Effects

drowsiness
dizziness
headache
nausea
diarrhoea
dry mouth
fatigue
next-day sleepiness

This is not an exhaustive list. Consult your doctor if you notice any unusual symptoms.

Important Warnings

Prescription-only sleep medicine. May cause next-day impairment, dizziness and falls—avoid driving/operating machinery after use. Risk of dependence, tolerance, misuse and withdrawal; use the lowest effective dose for the shortest duration. Complex sleep behaviours (sleep-walking/driving/eating) can occur—stop and seek medical help if these occur. Use with caution in elderly, liver impairment, respiratory disease/sleep apnoea, depression or history of substance use. Do not use with other sedatives unless advised. Seek urgent care for severe allergy, confusion, hallucinations or suicidal thoughts.

Drug Interactions

Zolpirest 5 may interact with the following:

Alcohol
opioids
benzodiazepines and other CNS depressants (additive sedation/respiratory depression); CYP3A4 inhibitors (e.g.
ketoconazole
clarithromycin
itraconazole
ritonavir) may increase levels; CYP3A4 inducers (e.g.
rifampicin
carbamazepine
phenytoin
St John’s wort) may reduce effect; caution with antidepressants/antipsychotics (increased CNS effects).

Always tell your doctor about all medicines you are taking, including over-the-counter drugs and supplements.

Pregnancy Safety

Use with caution / Consult doctor

Alcohol Interaction

Avoid

Habit Forming

Yes

Storage

Store below 25°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.

Zolpirest 5 — Safety Summary

Composition: Zolpidem tartrate 5 mg
Prescription: Required (Rx)
Pregnancy: Use with caution / Consult doctor
Alcohol: Avoid
Habit forming: Yes

Zolpirest 5 — Safety FAQs

What should I do if I experience side effects?

Mild side effects often resolve on their own. If side effects are severe or persistent, stop the medicine and consult your doctor immediately.

Are all listed side effects common?

No. Some side effects are common while others are rare. Not everyone experiences side effects. Consult your doctor if you are concerned.

Can I take this medicine with other drugs?

Some medicines interact with each other. Always inform your doctor about all medicines you are currently taking.

When should I seek emergency help?

Seek immediate medical attention if you experience severe allergic reactions (difficulty breathing, swelling of face/throat), chest pain, or any life-threatening symptoms.

Get help from a doctor

Consult a doctor

Discuss side effects with a qualified doctor online.

View all medicines

Full product details for Zolpirest 5.

Lab tests

Book tests to monitor your health while on medication.

Sick leave certificate

Unwell and need rest? A doctor can issue a leave certificate online, from ₹499.

Safety disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice. If you experience severe side effects, seek medical attention immediately.