Zolpirest 5

Composition of Zolpirest 5

Zolpirest 5 contains Zolpidem tartrate 5 mg. It belongs to the Non-benzodiazepine hypnotic (imidazopyridine; GABA-A receptor modulator) class of medicines.

Uses of Zolpirest 5

Short-term treatment of insomnia (difficulty falling asleep and/or frequent night awakenings)

Key benefits

• Helps fall asleep faster
• Improves sleep duration
• Reduces night-time awakenings
• Provides short-term relief from insomnia symptoms

How Zolpirest 5 works

Zolpidem is a non-benzodiazepine hypnotic that enhances the effect of GABA at the GABA-A receptor (preferentially via BZ1/alpha-1 subunits). This reduces neuronal activity in the brain and promotes sleep onset and maintenance.

How to take Zolpirest 5

Take exactly as prescribed by your doctor.

Side effects of Zolpirest 5

Most side effects of Zolpirest are mild and settle as the body adjusts. Reported side effects include:

• drowsiness
• dizziness
• headache
• nausea
• diarrhoea
• dry mouth
• fatigue
• next-day sleepiness

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Zolpirest 5

Warnings and precautions

Prescription-only sleep medicine. May cause next-day impairment, dizziness and falls—avoid driving/operating machinery after use. Risk of dependence, tolerance, misuse and withdrawal; use the lowest effective dose for the shortest duration. Complex sleep behaviours (sleep-walking/driving/eating) can occur—stop and seek medical help if these occur. Use with caution in elderly, liver impairment, respiratory disease/sleep apnoea, depression or history of substance use. Do not use with other sedatives unless advised. Seek urgent care for severe allergy, confusion, hallucinations or suicidal thoughts.

Interactions with other medicines

Alcohol, opioids, benzodiazepines and other CNS depressants (additive sedation/respiratory depression); CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, itraconazole, ritonavir) may increase levels; CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenytoin, St John’s wort) may reduce effect; caution with antidepressants/antipsychotics (increased CNS effects).

How to store Zolpirest 5

Store below 25°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.

Manufacturer and class

Manufacturer:

EAST WEST PHARMA

Therapeutic class:

Hypnotic/Sedative (Sleep aid)

Drug class:

Non-benzodiazepine hypnotic (imidazopyridine; GABA-A receptor modulator)