Zoryl Mf 1

Composition of Zoryl Mf 1

Zoryl Mf 1 contains Glimepiride (1mg) + Metformin (850mg). It belongs to the Sulfonylurea + Biguanide (Metformin) combination class of medicines.

Uses of Zoryl Mf 1

Type 2 diabetes mellitus in adults when blood sugar is not adequately controlled with diet/exercise and metformin or sulfonylurea alone; helps control fasting and post‑meal glucose.

Key benefits

• Lowers fasting and post-meal blood glucose
• Improves overall glycaemic control (HbA1c)
• Combination therapy in one tablet for convenience
• May reduce insulin resistance (metformin component)

How Zoryl Mf 1 works

Glimepiride (a sulfonylurea) increases insulin release from the pancreas and improves insulin sensitivity. Metformin reduces glucose production by the liver and decreases intestinal glucose absorption while improving peripheral glucose uptake. Together they lower blood glucose more effectively than either alone.

How to take Zoryl Mf 1

Oral tablets. Take exactly as prescribed, usually once daily with or just after food (commonly with breakfast). Swallow whole; do not crush/chew if MR/SR. Regularly monitor blood glucose; maintain diet and exercise plan.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take the missed dose of Zoryl Mf as soon as you remember. If it is almost time for the next dose, skip the missed one and carry on with the usual schedule. Do not take two doses together to make up for a missed dose.

If you take too much

Taking more Zoryl Mf than prescribed can be harmful. If you suspect an overdose, contact a doctor or go to the nearest emergency department at once, and carry the pack or strip with you. In India the emergency number is 112.

Side effects of Zoryl Mf 1

Most side effects of Zoryl Mf are mild and settle as the body adjusts. Reported side effects include:

• Hypoglycaemia (low blood sugar)
• nausea
• diarrhoea
• abdominal pain
• flatulence
• metallic taste
• headache
• dizziness
• weight gain
• skin rash

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Zoryl Mf 1

Warnings and precautions

Risk of hypoglycaemia (especially if meals are skipped, excessive exercise, alcohol use, or with other antidiabetics); carry glucose. Metformin may rarely cause lactic acidosis—risk increases with kidney impairment, dehydration, severe infection, heart/respiratory failure, liver disease, and heavy alcohol use. Check renal function before starting and periodically; avoid/use with caution in moderate renal impairment and do not use in severe renal impairment as advised by doctor. Temporarily stop metformin around iodinated contrast imaging and major surgery as directed. Use caution in elderly and in patients with G6PD deficiency (risk of haemolysis with sulfonylureas).

Interactions with other medicines

Insulin/other antidiabetics (increased hypoglycaemia), alcohol (increased hypoglycaemia and lactic acidosis risk), iodinated contrast media (lactic acidosis risk), ACE inhibitors (may enhance glucose-lowering), corticosteroids/thiazide diuretics/sympathomimetics (may raise glucose), beta-blockers (may mask hypoglycaemia symptoms), fluoroquinolones (glucose disturbances), azole antifungals and macrolides (may increase sulfonylurea effect), rifampicin (may reduce sulfonylurea effect), cimetidine (may increase metformin levels)

How to store Zoryl Mf 1

Store below 25°C in a dry place, protected from light and moisture. Keep in original blister pack and out of reach of children.

Expert advice for Zoryl Mf 1

<div class="style__desktop-container___1hcBT"><div class="style__desktop-video___2GTR9"><div class="styles__video-img___1rCzR"><div class=""/><div class=""/></div></div><div><div><div><div><div class="ExpertAdviceItem__content___1Djk2"><ul><li><div>You have been prescribed this combination medicine as it can control blood sugar better than metformin alone.</div></li> <li>You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Zoryl MF 1 Tablet.</li> <li>Take it with food to lower your chance of having an upset stomach.</li> <li>Monitor your blood sugar level regularly while you are taking this medicine. </li> <li>Inform your doctor about your diabetes treatment if you are due to have surgery under a general anesthetic.</li> <li>It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal. </li> <li>Tell your doctor immediately if you experience any deep or rapid breathing or if you have persistent nausea, vomiting, and stomach pain as Zoryl MF 1 Tablet may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.</li> <li>Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).</li></ul></div></div></div></div></div></div>

Manufacturer and class

Manufacturer:

Intas Pharmaceuticals Ltd

Marketed by:

INTAS PHARMACEUTICALS`

Therapeutic class:

diabetes

Drug class:

Sulfonylurea + Biguanide (Metformin) combination