Zoryl Mf 1

Glimepiride (1mg) + Metformin (850mg)

Type 2 diabetes mellitus in adults when blood sugar is not adequately controlled with diet/exercise and metformin or sulfonylurea alone; helps control fasting and post‑meal glucose.

Glimepiride (a sulfonylurea) increases insulin release from the pancreas and improves insulin sensitivity. Metformin reduces glucose production by the liver and decreases intestinal glucose absorption while improving peripheral glucose uptake. Together they lower blood glucose more effectively than either alone.

Oral tablets. Take exactly as prescribed, usually once daily with or just after food (commonly with breakfast). Swallow whole; do not crush/chew if MR/SR. Regularly monitor blood glucose; maintain diet and exercise plan.

Hypoglycaemia (low blood sugar), nausea, diarrhoea, abdominal pain, flatulence, metallic taste, headache, dizziness, weight gain, skin rash

Risk of hypoglycaemia (especially if meals are skipped, excessive exercise, alcohol use, or with other antidiabetics); carry glucose. Metformin may rarely cause lactic acidosis—risk increases with kidney impairment, dehydration, severe infection, heart/respiratory failure, liver disease, and heavy alcohol use. Check renal function before starting and periodically; avoid/use with caution in moderate renal impairment and do not use in severe renal impairment as advised by doctor. Temporarily stop metformin around iodinated contrast imaging and major surgery as directed. Use caution in elderly and in patients with G6PD deficiency (risk of haemolysis with sulfonylureas).

Insulin/other antidiabetics (increased hypoglycaemia), alcohol (increased hypoglycaemia and lactic acidosis risk), iodinated contrast media (lactic acidosis risk), ACE inhibitors (may enhance glucose-lowering), corticosteroids/thiazide diuretics/sympathomimetics (may raise glucose), beta-blockers (may mask hypoglycaemia symptoms), fluoroquinolones (glucose disturbances), azole antifungals and macrolides (may increase sulfonylurea effect), rifampicin (may reduce sulfonylurea effect), cimetidine (may increase metformin levels)

Store below 25°C in a dry place, protected from light and moisture. Keep in original blister pack and out of reach of children.

Glycomet GP 1 SR, Amaryl M 1, Glimy M 1 SR, Glimestar M1 SR, Diapride M 1 SR