Zoryl Ms Ir 2/1000

Composition of Zoryl Ms Ir 2/1000

Zoryl Ms Ir 2/1000 contains Sitagliptin (50mg) + Glimepiride (2mg) + Metformin (1000mg). It belongs to the Sulfonylurea + Biguanide class of medicines.

Uses of Zoryl Ms Ir 2/1000

• Type 2 diabetes mellitus: to improve blood glucose control in adults when diet and exercise alone are not sufficient
• or when dual therapy with sulfonylurea and metformin is appropriate

Key benefits

• Lowers fasting and post-meal blood glucose
• Improves insulin sensitivity and reduces liver glucose production
• Helps achieve HbA1c targets with dual therapy
• Convenient combination may reduce pill burden

How to take Zoryl Ms Ir 2/1000

Oral tablet. Take exactly as prescribed, usually with food to reduce stomach upset (commonly with breakfast or the first main meal). Swallow with water; do not skip meals as it may increase risk of low blood sugar. Dose is individualized based on blood glucose/HbA1c and kidney function.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Side effects of Zoryl Ms Ir 2/1000

Most side effects of Zoryl Ms Ir 2/1000 are mild and settle as the body adjusts. Reported side effects include:

• Hypoglycaemia
• nausea
• vomiting
• diarrhoea
• abdominal pain
• loss of appetite
• metallic taste
• headache
• dizziness
• weight gain
• skin rash

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Zoryl Ms Ir 2/1000

Warnings and precautions

Risk of hypoglycaemia (higher with missed meals, alcohol, excessive exercise, elderly, kidney/liver impairment); carry glucose and monitor sugars regularly. Metformin can rarely cause lactic acidosis—risk increases with severe kidney impairment, dehydration, sepsis, hypoxia/heart failure, excessive alcohol; stop and seek urgent care if rapid breathing, severe weakness, drowsiness, abdominal pain occur. Avoid/use with caution in renal impairment; monitor eGFR periodically and consider withholding around major surgery or severe illness. Temporarily stop metformin before/at time of iodinated contrast studies in patients at risk of renal impairment, and restart after renal function is stable. Long-term metformin may cause vitamin B12 deficiency; consider periodic monitoring. Use caution in hepatic disease and in G6PD deficiency (risk of haemolysis with sulfonylureas).

Do not take Zoryl Ms Ir 2/1000 if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney or liver disease. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis.