Zoryl Ms Ir 2/1000

Composition of Zoryl Ms Ir 2/1000

Zoryl Ms Ir 2/1000 contains Sitagliptin (50mg) + Glimepiride (2mg) + Metformin (1000mg). It belongs to the Sulfonylurea + Biguanide class of medicines.

Uses of Zoryl Ms Ir 2/1000

• Type 2 diabetes mellitus: to improve blood glucose control in adults when diet and exercise alone are not sufficient
• or when dual therapy with sulfonylurea and metformin is appropriate

Key benefits

• Lowers fasting and post-meal blood glucose
• Improves insulin sensitivity and reduces liver glucose production
• Helps achieve HbA1c targets with dual therapy
• Convenient combination may reduce pill burden

How Zoryl Ms Ir 2/1000 works

Glimepiride (a sulfonylurea) stimulates pancreatic beta cells to release insulin and improves peripheral glucose utilization. Metformin (a biguanide) decreases hepatic glucose production and improves insulin sensitivity, reducing intestinal glucose absorption.

How to take Zoryl Ms Ir 2/1000

Oral tablet. Take exactly as prescribed, usually with food to reduce stomach upset (commonly with breakfast or the first main meal). Swallow with water; do not skip meals as it may increase risk of low blood sugar. Dose is individualized based on blood glucose/HbA1c and kidney function.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

If you miss a dose of Zoryl MS 50mg/2mg/1000mg Tablet IR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

If you take too much

Taking more Zoryl Ms Ir 2/1000 than prescribed can be harmful. If you suspect an overdose, contact a doctor or go to the nearest emergency department at once, and carry the pack or strip with you. In India the emergency number is 112.

Side effects of Zoryl Ms Ir 2/1000

Most side effects of Zoryl Ms Ir 2/1000 are mild and settle as the body adjusts. Reported side effects include:

• Hypoglycaemia
• nausea
• vomiting
• diarrhoea
• abdominal pain
• loss of appetite
• metallic taste
• headache
• dizziness
• weight gain
• skin rash

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Zoryl Ms Ir 2/1000

Warnings and precautions

Risk of hypoglycaemia (higher with missed meals, alcohol, excessive exercise, elderly, kidney/liver impairment); carry glucose and monitor sugars regularly. Metformin can rarely cause lactic acidosis—risk increases with severe kidney impairment, dehydration, sepsis, hypoxia/heart failure, excessive alcohol; stop and seek urgent care if rapid breathing, severe weakness, drowsiness, abdominal pain occur. Avoid/use with caution in renal impairment; monitor eGFR periodically and consider withholding around major surgery or severe illness. Temporarily stop metformin before/at time of iodinated contrast studies in patients at risk of renal impairment, and restart after renal function is stable. Long-term metformin may cause vitamin B12 deficiency; consider periodic monitoring. Use caution in hepatic disease and in G6PD deficiency (risk of haemolysis with sulfonylureas).

Interactions with other medicines

Alcohol (increases hypoglycaemia/lactic acidosis risk), insulin/other antidiabetics (additive hypoglycaemia), beta-blockers (may mask hypoglycaemia symptoms), ACE inhibitors (may enhance glucose-lowering), corticosteroids and thiazide diuretics (may raise glucose), fluoroquinolones (may cause hypo/hyperglycaemia), rifampicin (may reduce sulfonylurea effect), azole antifungals and macrolides (may increase sulfonylurea effect), NSAIDs/salicylates (may enhance hypoglycaemia), cimetidine and other OCT2/MATE inhibitors (may increase metformin levels), iodinated contrast media (risk of lactic acidosis with renal dysfunction)

How to store Zoryl Ms Ir 2/1000

Store below 25°C in a dry place, protected from light and moisture. Keep in original blister pack and out of reach of children.

Expert advice for Zoryl Ms Ir 2/1000

Prefer taking Zoryl MS 50mg/2mg/1000mg Tablet IR after a meal or with a snack, as this will reduce the chance of an upset stomach. Zoryl MS 50mg/2mg/1000mg Tablet IR may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal. Always carry some sugary food or fruit juice with you in case you experience hypoglycemia (low blood sugar) symptoms, such as fatigue, dizziness, cold sweats, tremor, and anxiety. If you get unusually thirsty, pass urine more frequently, and feel tired, let your doctor know. These are signs that there is too much sugar in your blood and your dose may need adjusting. Monitor your blood sugar regularly while taking this medicine. Lifestyle changes like low sugar diet, exercising, losing weight, not smoking, and cutting down on alcohol intake may help this medication work better.

Manufacturer and class

Manufacturer:

INTAS PHARMACEUTICALS`

Therapeutic class:

Antidiabetic

Drug class:

Sulfonylurea + Biguanide