Prescription requiredAntidiabetic

ZORYL MS IR 2/1000 — Side Effects & Warnings

Known side effects of ZORYL MS IR 2/1000 include Hypoglycaemia, nausea, vomiting, diarrhoea, abdominal pain, loss of appetite, metallic taste, headache, dizziness, weight gain, skin rash. Not everyone experiences these side effects.

Common Side Effects

Hypoglycaemia
nausea
vomiting
diarrhoea
abdominal pain
loss of appetite
metallic taste
headache
dizziness
weight gain
skin rash

This is not an exhaustive list. Consult your doctor if you notice any unusual symptoms.

Important Warnings

Risk of hypoglycaemia (higher with missed meals, alcohol, excessive exercise, elderly, kidney/liver impairment); carry glucose and monitor sugars regularly. Metformin can rarely cause lactic acidosis—risk increases with severe kidney impairment, dehydration, sepsis, hypoxia/heart failure, excessive alcohol; stop and seek urgent care if rapid breathing, severe weakness, drowsiness, abdominal pain occur. Avoid/use with caution in renal impairment; monitor eGFR periodically and consider withholding around major surgery or severe illness. Temporarily stop metformin before/at time of iodinated contrast studies in patients at risk of renal impairment, and restart after renal function is stable. Long-term metformin may cause vitamin B12 deficiency; consider periodic monitoring. Use caution in hepatic disease and in G6PD deficiency (risk of haemolysis with sulfonylureas).

Drug Interactions

ZORYL MS IR 2/1000 may interact with the following:

Alcohol (increases hypoglycaemia/lactic acidosis risk)
insulin/other antidiabetics (additive hypoglycaemia)
beta-blockers (may mask hypoglycaemia symptoms)
ACE inhibitors (may enhance glucose-lowering)
corticosteroids and thiazide diuretics (may raise glucose)
fluoroquinolones (may cause hypo/hyperglycaemia)
rifampicin (may reduce sulfonylurea effect)
azole antifungals and macrolides (may increase sulfonylurea effect)
NSAIDs/salicylates (may enhance hypoglycaemia)
cimetidine and other OCT2/MATE inhibitors (may increase metformin levels)
iodinated contrast media (risk of lactic acidosis with renal dysfunction)

Always tell your doctor about all medicines you are taking, including over-the-counter drugs and supplements.

Pregnancy Safety

Not recommended; consult doctor (insulin is generally preferred in pregnancy)

Alcohol Interaction

Avoid

Habit Forming

Storage

Store below 25°C in a dry place, protected from light and moisture. Keep in original blister pack and out of reach of children.

ZORYL MS IR 2/1000 — Safety Summary

Composition: Glimepiride 2 mg + Metformin 1000 mg (immediate-release) tablet
Prescription: Required (Rx)
Pregnancy: Not recommended; consult doctor (insulin is generally preferred in pregnancy)
Alcohol: Avoid
Habit forming: No

ZORYL MS IR 2/1000 — Safety FAQs

What should I do if I experience side effects?

Mild side effects often resolve on their own. If side effects are severe or persistent, stop the medicine and consult your doctor immediately.

Are all listed side effects common?

No. Some side effects are common while others are rare. Not everyone experiences side effects. Consult your doctor if you are concerned.

Can I take this medicine with other drugs?

Some medicines interact with each other. Always inform your doctor about all medicines you are currently taking.

When should I seek emergency help?

Seek immediate medical attention if you experience severe allergic reactions (difficulty breathing, swelling of face/throat), chest pain, or any life-threatening symptoms.

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Safety disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice. If you experience severe side effects, seek medical attention immediately.