Use with caution in hypertension, heart disease, hyperthyroidism, diabetes, glaucoma, enlarged prostate/urinary retention, and kidney impairment. May cause insomnia, nervousness or palpitations; avoid late-evening dosing if it affects sleep. Do not use with other decongestants or stimulant-containing cold medicines without advice. Seek medical help for chest pain, severe headache, significant rise in BP, or allergic reaction.