Pregal M 50

Composition of Pregal M 50

Pregal M 50 contains Pregabalin (50mg) + Mecobalamin (750mcg). It belongs to the Gabapentinoid (pregabalin) + Vitamin B12 analog (methylcobalamin) class of medicines.

Uses of Pregal M 50

• Neuropathic pain (e.g.
• diabetic neuropathy
• post-herpetic neuralgia)
• nerve pain due to vitamin B12 deficiency
• tingling/numbness in peripheral neuropathy

Key benefits

• Relieves neuropathic (nerve) pain
• Reduces burning/tingling/numbness
• Improves nerve function and myelin repair
• Helps in diabetic/peripheral neuropathy
• Supports vitamin B12 replenishment

How Pregal M 50 works

Pregabalin reduces abnormal nerve signaling by binding to the alpha-2-delta subunit of voltage-gated calcium channels in the CNS, decreasing release of pain neurotransmitters. Methylcobalamin is an active form of vitamin B12 that supports myelin sheath repair and nerve regeneration, helping improve neuropathic symptoms.

How to take Pregal M 50

Take by mouth as prescribed, usually once or twice daily; may be taken with or without food. Swallow whole with water; do not crush/chew. Do not stop suddenly—dose should be tapered under medical supervision.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can cause deep drowsiness, confusion, unsteadiness and slowed breathing, especially with an opioid or alcohol. It is unlikely to cause serious harm, because the body passes surplus B vitamins out in the urine. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Pregal M 50

Most side effects of Pregal M are mild and settle as the body adjusts. Reported side effects include:

• Dizziness
• drowsiness
• fatigue
• blurred vision
• dry mouth
• weight gain
• peripheral edema (swelling)
• constipation
• difficulty concentrating

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Pregal M 50

Warnings and precautions

May cause dizziness and sleepiness—avoid driving or operating machinery until you know the effect. Use with caution in kidney disease (dose adjustment needed) and in elderly. Risk of swelling/edema and weight gain; caution in heart failure. Do not discontinue abruptly (may cause withdrawal symptoms). Rarely, mood changes or suicidal thoughts—seek medical help if they occur. Hypersensitivity reactions (rash, facial swelling) require urgent care.

Do not take Pregal M if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack.

Interactions with other medicines

Alcohol and other CNS depressants (increased drowsiness), opioids (e.g., tramadol, morphine) and benzodiazepines (additive sedation/respiratory depression risk), antihistamines/sedatives, ACE inhibitors (may increase risk of angioedema), medicines causing edema

How to store Pregal M 50

Store at room temperature (below 25°C), protected from moisture and light. Keep in original blister pack and out of reach of children.

Expert advice for Pregal M 50

Take the larger part of the dose at night if drowsiness is a problem. Rise slowly from sitting or lying, especially in the first weeks. Keep your review appointment so the dose can be adjusted to the lowest that controls your pain. A supplement corrects a deficiency; it is not a general energy tonic. If you are on it for nerve symptoms, keep your review appointment so the underlying cause is looked for.

Manufacturer and class

Manufacturer:

PRESCRIPTO LIFE SCIENCE

Therapeutic class:

Neuropathic pain agent (with vitamin supplement)

Drug class:

Gabapentinoid (pregabalin) + Vitamin B12 analog (methylcobalamin)