Drug | Tablet

Treatment of abnormal uterine bleeding (dysfunctional uterine bleeding), secondary amenorrhoea, endometriosis; to postpone/shift menstruation; management of menstrual disorders such as irregular, heavy or painful periods (as prescribed).

Norethisterone is a synthetic progestin (progesterone-like hormone). It converts the proliferative endometrium to a secretory endometrium and stabilizes the uterine lining, reducing bleeding. Withdrawal of the hormone after stopping the tablets triggers a menstrual-like bleed.

Tablet for oral use. Take exactly as prescribed by your doctor; dosing depends on the condition (e.g., for period delay often started a few days before expected menses and continued as advised). Can be taken with or without food; take at the same time each day and do not stop abruptly unless advised.

Nausea, headache, dizziness, breast tenderness, abdominal pain or bloating, spotting/breakthrough bleeding, change in menstrual flow, mood changes, weight gain, acne, fatigue

Use only under medical supervision. Not recommended in pregnancy; rule out pregnancy before starting for amenorrhoea/bleeding. Caution/avoid in history of thromboembolism (DVT/PE), stroke, severe liver disease, liver tumors, unexplained vaginal bleeding, hormone-dependent cancers (e.g., breast/genital tract) unless directed by a specialist. May increase risk of blood clots; seek urgent care for leg swelling/pain, chest pain, shortness of breath, severe headache or vision changes. Use caution in diabetes, hypertension, migraine, depression, and smokers, especially >35 years.

Enzyme inducers may reduce effect: rifampicin/rifabutin, phenytoin, carbamazepine, phenobarbital, primidone, topiramate, some antiretrovirals, St. John’s wort. May affect glucose tolerance (monitor with antidiabetics). Concomitant hormonal therapies may alter bleeding pattern/effect.

Store below 25°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.

Primolut N 5 mg Tablet, Norest 5 mg Tablet, Norlut N 5 mg Tablet, Norethisterone 5 mg Tablet (generic), Regestrone 5 mg Tablet (other pack sizes)