Drug | Capsule

Prevention of cardiovascular events (heart attack, stroke) in patients at high risk; management of dyslipidaemia (high LDL cholesterol/triglycerides) with need for antiplatelet therapy; secondary prevention in coronary artery disease/after angioplasty or stenting as prescribed

Rosuvastatin is an HMG‑CoA reductase inhibitor that reduces cholesterol synthesis in the liver, lowering LDL and triglycerides and modestly raising HDL. Aspirin irreversibly inhibits platelet COX‑1, reducing thromboxane A2 formation and thereby decreasing platelet aggregation and clot formation.

Take orally once daily as prescribed, preferably at the same time each day, with or without food. Swallow the capsule whole (do not crush/chew, especially if enteric-coated aspirin component). Do not stop on your own; continue long-term unless advised by your doctor.

Stomach upset/heartburn, nausea, abdominal pain, easy bruising, nosebleed, headache, dizziness, muscle pain (myalgia), weakness, raised liver enzymes

Risk of bleeding (especially with ulcers, recent surgery, bleeding disorders); seek urgent care for black stools, vomiting blood, unusual bleeding/bruising. Rosuvastatin may cause muscle injury (myopathy/rhabdomyolysis); report unexplained muscle pain, tenderness, dark urine. Monitor liver function; use caution in liver disease and heavy alcohol use. Not recommended in active liver disease; dose adjustments/close monitoring in severe kidney impairment. Avoid in aspirin allergy, asthma with aspirin sensitivity, and in children/teens with viral illness (Reye’s syndrome risk). Inform doctor before procedures/dental work; do not combine with other NSAIDs/antiplatelets unless advised.

Warfarin and other anticoagulants (increased bleeding), clopidogrel/ticagrelor and other antiplatelets (bleeding risk), NSAIDs (GI bleeding), SSRIs/SNRIs (bleeding risk), corticosteroids (GI ulcer/bleeding), methotrexate (toxicity), other statins/fibrates (myopathy risk), cyclosporine (increases rosuvastatin levels), protease inhibitors (increase statin levels), antacids containing aluminium/magnesium (reduce rosuvastatin absorption; separate by at least 2 hours), colchicine (myopathy risk)

Store below 25°C in a dry place, protected from moisture and light. Keep in original pack and out of reach of children.

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