Drug | Injection

Short-term management of severe anxiety and agitation, acute seizures/status epilepticus, premedication and procedural sedation, muscle spasm/spasticity (e.g., tetanus), alcohol withdrawal symptoms (including delirium tremens)

Diazepam is a benzodiazepine that enhances the effect of GABA (an inhibitory neurotransmitter) by binding to GABA-A receptors. This increases chloride influx into neurons, producing anxiolytic, sedative, anticonvulsant and muscle-relaxant effects.

Injection for use only under medical supervision. Given as slow IV injection/IV infusion or deep IM injection as prescribed; dose and rate depend on indication, age and clinical response. Avoid rapid IV administration; monitor breathing, blood pressure and level of sedation.

Drowsiness, dizziness, sedation, muscle weakness, confusion, ataxia, injection site pain/irritation, low blood pressure, respiratory depression

Schedule X medicine: use strictly on prescription and under supervision. Risk of respiratory depression, excessive sedation and hypotension—higher in elderly, debilitated patients, and with other CNS depressants. Use with caution in liver disease, COPD/sleep apnoea, myasthenia gravis, depression/suicidality. May cause dependence, tolerance and withdrawal; avoid abrupt discontinuation after repeated doses. Do not drive/operate machinery after receiving. IV use requires resuscitation facilities.

Alcohol and other CNS depressants (opioids, barbiturates, sedating antihistamines, antipsychotics) increase sedation/respiratory depression; opioids carry high risk of profound sedation/coma. CYP inhibitors (cimetidine, omeprazole, fluoxetine, fluvoxamine, azole antifungals, macrolides) may increase diazepam levels. CYP inducers (rifampicin, carbamazepine, phenytoin, phenobarbital) may reduce effect. Valproate may increase sedation. Theophylline/caffeine may reduce sedative effect.

Store below 25°C, protected from light. Do not freeze. Keep in original pack until use; discard if solution is discoloured or contains particles.

Calmpose Injection, Valium Injection, Diazepam Injection IP (various brands), Anxicalm Injection, Diazem Injection