Intas Pharmaceuticals Ltd
Zoryl-MD 1/500 mg Tablet
Tablet · 1mg + 500mg · 10 S
₹134.06
Prescription needed
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MRP, inclusive of all taxes
Delivered across India. ₹49 delivery, free above ₹999.
Pack: 10`S
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Contains: Glimepiride (1mg) + Metformin (1000mg) + Sitagliptin (50mg)
Zoryl Ms Ir 1/1000 contains Glimepiride (1mg) + Metformin (1000mg) + Sitagliptin (50mg). Prescription required.
Zoryl Ms Ir 1/1000 is a prescription medicine containing Glimepiride (1mg) + Metformin (1000mg) + Sitagliptin (50mg). It is used for type 2 diabetes mellitus in adults when diet, exercise alone are not sufficient and used to improve blood glucose control. It belongs to the group of medicines called Sulfonylurea + Biguanide.
Take orally as prescribed, usually with/after meals to reduce stomach upset. The dose and how long you take it depend on what you are being treated for and how you respond. Do not take more, or for longer, than your doctor has advised.
The side effects seen most often with Zoryl Ms Ir 1/1000 are hypoglycaemia, nausea, vomiting and diarrhoea. Most are mild and settle as the body gets used to the medicine. Tell your doctor if one persists or worries you.
Before you start, tell your doctor about any liver, kidney or heart problem, whether you are pregnant, planning a pregnancy or breastfeeding, and every other medicine you take, including supplements and ayurvedic preparations. Some of them can change how Zoryl Ms Ir 1/1000 works.
Most side effects of Zoryl Ms Ir 1/1000 are mild and settle as the body gets used to the medicine. The ones reported most often are:
Stop the medicine and get help at once for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
Take orally as prescribed, usually with/after meals to reduce stomach upset. Swallow tablet whole with water; do not crush unless advised. Monitor blood glucose regularly; dose is individualized based on control and tolerability.
Glimepiride (a sulfonylurea) increases insulin release from the pancreas and improves peripheral glucose utilization. Metformin (a biguanide) reduces glucose production in the liver and improves insulin sensitivity, helping lower fasting and post‑meal blood sugar.
Risk of hypoglycaemia (especially with missed meals, alcohol, strenuous exercise, or with other antidiabetics); carry glucose source. Metformin can rarely cause lactic acidosis—risk increases with kidney impairment, dehydration, severe infection, heart/respiratory failure, or heavy alcohol use. Avoid/adjust in renal impairment; check eGFR before and during therapy. Temporarily stop metformin before iodinated contrast procedures or major surgery as advised. Use caution in liver disease; may cause vitamin B12 deficiency with long-term use. Not for type 1 diabetes or diabetic ketoacidosis.
Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.
An overdose of this medicine can cause severe and prolonged low blood sugar, which may lead to fits or unconsciousness. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. It may cause low blood sugar, particularly if you also take other diabetes medicines. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Alcohol (increases hypoglycaemia/lactic acidosis risk), insulin/other antidiabetics (additive hypoglycaemia), beta-blockers (mask hypoglycaemia symptoms), corticosteroids/thiazides (raise glucose), ACE inhibitors (may enhance glucose-lowering), rifampicin (reduces sulfonylurea effect), azole antifungals/fluoroquinolones/salicylates (may increase hypoglycaemia), iodinated contrast media (lactic acidosis risk with metformin), cimetidine (raises metformin levels)
Store below 25°C in a cool, dry place. Protect from moisture and light. Keep out of reach of children.
Amaryl M 1/1000 Tablet, Glimy M 1/1000 Tablet, Glycomet-GP 1/1000 Tablet, Gemer 1/1000 Tablet, Gluconorm-G 1/1000 Tablet
Compiled from the manufacturer's prescribing information and the sources below, and reviewed by a registered pharmacist. It does not replace your own doctor's advice.
Medical disclaimer: product information is for awareness only and does not replace medical advice. For Rx medicines, a valid prescription is required. Consult your doctor or pharmacist for personalised guidance.
Intas Pharmaceuticals Ltd
Tablet · 1mg + 500mg · 10 S
₹134.06
Prescription needed