Drug | Tablet

Treatment and prevention of hyperuricemia and gout, prevention of recurrent gout attacks, prevention of uric acid/kidney stone formation, prevention of high uric acid during cancer chemotherapy (tumor lysis syndrome)

Allopurinol inhibits xanthine oxidase, the enzyme responsible for converting hypoxanthine and xanthine into uric acid. This reduces uric acid production and lowers serum and urinary urate levels, helping prevent crystal deposition and gout flares over time.

Take exactly as prescribed, usually once daily after food to reduce stomach upset. Swallow with water and maintain good hydration. Do not stop suddenly; it is not used to treat an acute gout attack—continue during attacks if already on it, as advised by the doctor.

Skin rash, nausea, vomiting, diarrhoea, abdominal pain, headache, drowsiness, dizziness, raised liver enzymes

Risk of serious hypersensitivity reactions (e.g., severe skin rash/Stevens-Johnson syndrome/TEN); stop and seek urgent care if rash, fever, mouth sores or swelling occurs. Dose adjustment is needed in kidney impairment; monitor kidney function, liver enzymes and blood counts as advised. Start with low dose and titrate to reduce gout flare risk; prophylaxis with NSAID/colchicine may be recommended initially. Use caution in liver disease. Inform doctor if you have HLA-B*58:01 risk (higher risk in some Asian populations) or history of allopurinol allergy.

Azathioprine, mercaptopurine (severe toxicity—dose adjustment/avoid), warfarin (increased anticoagulant effect), theophylline, didanosine, ampicillin/amoxicillin (increased rash risk), thiazide diuretics (increased hypersensitivity risk), ACE inhibitors (increased hypersensitivity risk), ciclosporin, cyclophosphamide

Store at room temperature (below 25°C), in a dry place away from moisture and direct light. Keep out of reach of children.

Allopurinol 100 mg Tablet (generic), Aloric 100 Tablet, Zyloprim 100 Tablet, Lopurin 100 Tablet, Allopurinol IP 100 mg Tablet