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Treatment of lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) and overactive bladder symptoms such as urinary frequency, urgency and urge incontinence.

Silodosin is a selective alpha-1A adrenergic blocker that relaxes smooth muscles in the prostate and bladder neck, improving urine flow and reducing BPH symptoms. Mirabegron is a beta-3 adrenergic agonist that relaxes the detrusor muscle during the storage phase, increasing bladder capacity and reducing urgency and frequency.

Take by mouth exactly as prescribed by the doctor, usually once daily. Preferably take at the same time each day; silodosin-containing products are commonly advised to be taken with food to reduce side effects. Swallow whole with water; do not crush or chew.

Dizziness,headache,diarrhoea,nasal congestion,retrograde ejaculation,low blood pressure on standing (orthostatic hypotension),increased heart rate (tachycardia),raised blood pressure,urinary tract infection

Use with caution in patients with low blood pressure, dizziness/falls risk, severe kidney disease or severe liver disease; dose adjustment may be needed based on renal function. Mirabegron can increase blood pressure—monitor BP, especially in hypertension; not recommended in severe uncontrolled hypertension. May cause dizziness—avoid driving/operating machinery if affected. Tell your doctor if you have urinary retention risk, bladder outlet obstruction, heart rhythm problems, or are on multiple BP medicines.

Strong CYP3A4 inhibitors (ketoconazole, itraconazole, ritonavir, clarithromycin) may increase silodosin levels; alpha-blockers with PDE5 inhibitors (sildenafil/tadalafil) or antihypertensives can increase hypotension risk. Mirabegron inhibits CYP2D6—can increase levels of metoprolol, desipramine, flecainide, propafenone, thioridazine; caution with digoxin (may increase digoxin levels) and other drugs that raise BP/HR.

Store at room temperature (below 25°C), protected from moisture and direct light. Keep in original blister pack and out of reach of children.