Prescription requiredAnti-acne

Aklief Cream — Side Effects & Warnings

Known side effects of Aklief Cream include Skin irritation, redness (erythema), dryness, peeling/scaling, burning/stinging, itching (pruritus), photosensitivity. Not everyone experiences these side effects.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated June 2026

Common Side Effects

Skin irritation
redness (erythema)
dryness
peeling/scaling
burning/stinging
itching (pruritus)
photosensitivity

This is not an exhaustive list. Consult your doctor if you notice any unusual symptoms.

Important Warnings

May cause irritation especially at start of therapy; avoid use on eczematous, sunburned, broken or abraded skin. Avoid excessive sun exposure and tanning lamps; use sunscreen and protective clothing. Do not apply to eyes, lips or mucosa; rinse with water if contact occurs. Use caution with other irritating topical products (scrubs, astringents, alcohol-based products). Not for oral use.

Drug Interactions

Aklief Cream may interact with the following:

Increased irritation with other topical retinoids
benzoyl peroxide
salicylic acid
alpha-hydroxy acids
abrasive cleansers or alcohol-based skincare; photosensitizing agents may increase sun sensitivity

Always tell your doctor about all medicines you are taking, including over-the-counter drugs and supplements.

Pregnancy Safety

Not recommended / Consult doctor

Alcohol Interaction

No known interaction

Habit Forming

Storage

Store at room temperature (below 25°C), protect from light and excessive heat. Keep cap tightly closed; do not freeze. Keep out of reach of children.

Aklief Cream — Safety Summary

Composition: Trifarotene 0.005% w/w cream
Prescription: Required (Rx)
Pregnancy: Not recommended / Consult doctor
Alcohol: No known interaction
Habit forming: No

Aklief Cream — Safety FAQs

What should I do if I experience side effects?

Mild side effects often resolve on their own. If side effects are severe or persistent, stop the medicine and consult your doctor immediately.

Are all listed side effects common?

No. Some side effects are common while others are rare. Not everyone experiences side effects. Consult your doctor if you are concerned.

Can I take this medicine with other drugs?

Some medicines interact with each other. Always inform your doctor about all medicines you are currently taking.

When should I seek emergency help?

Seek immediate medical attention if you experience severe allergic reactions (difficulty breathing, swelling of face/throat), chest pain, or any life-threatening symptoms.

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Safety disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice. If you experience severe side effects, seek medical attention immediately.