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Prescription requiredGalderma India Pvt LtdAnti-acne

Aklief Cream

Trifarotene 0.005% w/w cream

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Aklief Cream is used for treatment of acne vulgaris (comedonal and inflammatory acne) on the face and/or trunk.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026

Licensed pharmacyPharmacist-verified order

Key details

Salt: Trifarotene 0.005% w/w cream
Available variants: cream 0.005%w/w 30GM
Best price: ₹941 (₹31.35 per g)
MRP: ₹990
Prescription: Required
Manufacturer: GALDERMA INDIA PVT LTD

Ordering notes

Delivery details are shown when the medicine is back in stock.
Returns & refunds: orders can be cancelled before dispatch; after dispatch, returns depend on the item category. Read the full policy

Composition of Aklief Cream

Aklief Cream contains Trifarotene 0.005% w/w cream. It belongs to the Topical retinoid (RAR-gamma selective retinoid) class of medicines.

Uses of Aklief Cream

Treatment of acne vulgaris (comedonal and inflammatory acne) on the face and/or trunk

Key benefits

  • Reduces comedones (blackheads/whiteheads)
  • Decreases inflammatory acne lesions
  • Helps prevent new acne formation
  • Improves overall skin texture with continued use

How Aklief Cream works

Trifarotene is a topical retinoid that selectively activates retinoic acid receptor (RAR)-gamma in the skin. It normalizes abnormal keratinization, helps prevent comedone formation, and reduces inflammation in acne lesions.

How to take Aklief Cream

For external use only. Apply a thin layer once daily in the evening to clean, dry affected areas (face and/or trunk) as advised by a dermatologist. Use a pea-sized amount for face; avoid eyes, lips, nostrils and mucous membranes. Moisturizer and sunscreen (SPF) are recommended; reduce frequency if irritation occurs.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Apply it as soon as you remember. If it is nearly time for the next application, skip the missed one — applying extra does not make up for it.

If you take too much

An overdose of this medicine can cause severe irritation when far too much cream is applied; an oral retinoid taken in excess can cause headache, vomiting and liver injury. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Aklief Cream

Most side effects of Aklief are mild and settle as the body adjusts. Reported side effects include:

  • Skin irritation
  • redness (erythema)
  • dryness
  • peeling/scaling
  • burning/stinging
  • itching (pruritus)
  • photosensitivity

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Aklief Cream

PregnancyNot recommended / Consult doctor
BreastfeedingNot recommended while breastfeeding.
AlcoholNo known interaction
DrivingNot expected to affect your ability to drive.
KidneyUse with caution if you have kidney disease — your doctor may adjust the dose or monitor your kidney function.
LiverConsult your doctor if you have liver disease.
Habit formingNo

Warnings and precautions

May cause irritation especially at start of therapy; avoid use on eczematous, sunburned, broken or abraded skin. Avoid excessive sun exposure and tanning lamps; use sunscreen and protective clothing. Do not apply to eyes, lips or mucosa; rinse with water if contact occurs. Use caution with other irritating topical products (scrubs, astringents, alcohol-based products). Not for oral use.

Do not take Aklief if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Oral retinoids are absolutely contraindicated in pregnancy and in anyone who might become pregnant without a pregnancy prevention programme. Topical retinoids are avoided in pregnancy.

Interactions with other medicines

Increased irritation with other topical retinoids, benzoyl peroxide, salicylic acid, alpha-hydroxy acids, abrasive cleansers or alcohol-based skincare; photosensitizing agents may increase sun sensitivity

How to store Aklief Cream

Store at room temperature (below 25°C), protect from light and excessive heat. Keep cap tightly closed; do not freeze. Keep out of reach of children.

Expert advice for Aklief Cream

Apply retinoids at night to clean, dry skin, and moisturise afterwards. Give it at least eight to twelve weeks before judging whether it works. Do not pick or squeeze spots — that is what leaves scars.

Manufacturer and class

Manufacturer:
GALDERMA INDIA PVT LTD
Therapeutic class:
Anti-acne
Drug class:
Topical retinoid (RAR-gamma selective retinoid)

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Aklief Cream FAQs

What is Aklief Cream used for?
Aklief Cream is commonly used for Treatment of acne vulgaris (comedonal and inflammatory acne) on the face and/or trunk. Always follow your doctor's advice, this information is for educational purposes and not a substitute for professional medical guidance.
What is the salt in Aklief Cream?
Aklief Cream contains Trifarotene 0.005% w/w cream. If you are allergic to any of these active ingredients or excipients, do not take this medicine and speak to your doctor first.
How should I take Aklief Cream?
For external use only. Take it exactly as prescribed; do not change the dose or stop early without talking to your doctor.
How does Aklief Cream work?
Trifarotene is a topical retinoid that selectively activates retinoic acid receptor (RAR)-gamma in the skin.
Is Aklief Cream a prescription medicine?
Yes. Aklief Cream is a prescription-only (Rx) medicine. Upload a valid prescription from a registered medical practitioner during checkout. We cannot dispense it without a valid Rx.
What are the common side effects of Aklief Cream?
The side effects reported most often with Aklief are Skin irritation, redness (erythema), dryness, peeling/scaling, burning/stinging. Most are mild and settle as the body adjusts; tell your doctor if any of them persist or worry you, and stop the medicine and seek help at once for a rash, swelling of the face or lips, or difficulty breathing.
Can Aklief Cream be taken during pregnancy?
Not recommended / Consult doctor Always tell your doctor if you are pregnant, planning a pregnancy or breastfeeding before starting Aklief.
Can I drink alcohol while taking Aklief Cream?
No known interaction
What if I miss a dose of Aklief Cream?
Apply it as soon as you remember.
Is Aklief Cream habit forming?
No. Aklief Cream is not known to be habit forming when taken as prescribed.
How much does Aklief Cream cost on PingMeDoc Pharmacy?
Aklief Cream starts at ₹941 (MRP ₹990) on PingMeDoc Pharmacy. Available in cream 0.005%w/w 30GM. Final price is confirmed at checkout and may vary by variant and location.
Who manufactures Aklief Cream?
Aklief Cream is manufactured by GALDERMA INDIA PVT LTD. PingMeDoc Pharmacy sources medicines only from licensed manufacturers and distributors.
How is Aklief Cream delivered?
Aklief Cream is delivered across India via our licensed pharmacy partners. Standard delivery timelines are confirmed at checkout. Chennai customers can opt for chargeable same-city express delivery.

Aklief Cream, Quick facts

Salt
Trifarotene 0.005% w/w cream
Form
cream
Best price
₹941 (₹31.35 per g)
MRP
₹990
Prescription
Required (Rx)
Brand
GALDERMA INDIA PVT LTD
Manufacturer
GALDERMA INDIA PVT LTD
Therapeutic class
Anti-acne
Drug class
Topical retinoid (RAR-gamma selective retinoid)
Habit forming
No
Variants
cream 0.005%w/w 30GM
Delivery
Standard across India

References

The information on Aklief Cream is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.

  1. Manufacturer labeling/prescribing information, established medical literature on topical retinoids, regulatory drug monographs
  2. Central Drugs Standard Control Organisation (CDSCO), Ministry of Health & Family Welfare, Government of India, approved drug and schedule listings.
  3. National List of Essential Medicines (NLEM) 2022, Government of India.
  4. Manufacturer's package insert / prescribing information for Aklief Cream.
  5. World Health Organization, ATC/DDD classification and Model Formulary for the active ingredient.

Next steps

Safety disclaimer

Product information is for general awareness and does not replace professional medical advice. Always follow a clinician's guidance and upload a valid prescription when required.