Prescription requiredAntibiotic

Augmentin Duo 375mg Tablet — Side Effects & Warnings

Known side effects of Augmentin Duo 375mg Tablet include Diarrhoea, nausea, vomiting, abdominal pain, indigestion, rash, urticaria, headache, dizziness, oral/vaginal candidiasis. Not everyone experiences these side effects.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated August 2026

Common Side Effects

Diarrhoea
nausea
vomiting
abdominal pain
indigestion
rash
urticaria
headache
dizziness
oral/vaginal candidiasis

This is not an exhaustive list. Consult your doctor if you notice any unusual symptoms.

Important Warnings

Prescription-only (Schedule H). Do not use if allergic to penicillins/cephalosporins or if you have had jaundice/liver dysfunction with amoxicillin-clavulanate. Use with caution in liver disease, renal impairment (dose adjustment may be needed), infectious mononucleosis (higher risk of rash), and history of severe allergy. Seek urgent care for signs of anaphylaxis (wheezing, facial swelling), severe skin reactions, persistent/bloody diarrhoea (possible C. difficile), or jaundice. May reduce effectiveness of oral typhoid vaccine.

Drug Interactions

Augmentin Duo 375mg Tablet may interact with the following:

Warfarin/other anticoagulants (increased bleeding risk/INR changes)
methotrexate (increased toxicity)
probenecid (increases amoxicillin levels)
allopurinol (increased risk of rash)
mycophenolate mofetil (reduced active metabolite exposure)
oral contraceptives (possible reduced efficacy—use backup if advised)

Always tell your doctor about all medicines you are taking, including over-the-counter drugs and supplements.

Pregnancy Safety

Consult doctor (generally considered safe when prescribed)

Alcohol Interaction

Use with caution

Habit Forming

Storage

Store below 25°C, protected from moisture and light. Keep in original pack and out of reach of children.

Augmentin Duo 375mg Tablet — Safety Summary

Composition: Amoxycillin (500mg) + Clavulanic Acid (125mg)
Prescription: Required (Rx)
Pregnancy: Consult doctor (generally considered safe when prescribed)
Alcohol: Use with caution
Habit forming: No

Augmentin Duo 375mg Tablet — Safety FAQs

What should I do if I experience side effects?

Mild side effects often resolve on their own. If side effects are severe or persistent, stop the medicine and consult your doctor immediately.

Are all listed side effects common?

No. Some side effects are common while others are rare. Not everyone experiences side effects. Consult your doctor if you are concerned.

Can I take this medicine with other drugs?

Some medicines interact with each other. Always inform your doctor about all medicines you are currently taking.

When should I seek emergency help?

Seek immediate medical attention if you experience severe allergic reactions (difficulty breathing, swelling of face/throat), chest pain, or any life-threatening symptoms.

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Safety disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice. If you experience severe side effects, seek medical attention immediately.