OTC · No prescriptionCough & Cold preparation (Antitussive/Antihistamine/Expectorant combination)

Benadryl CR Syp — Side Effects & Warnings

Known side effects of Benadryl CR Syp include Drowsiness, dizziness, dry mouth, constipation, blurred vision, nausea, stomach upset, thickened bronchial secretions. Not everyone experiences these side effects.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated June 2026

Common Side Effects

Drowsiness
dizziness
dry mouth
constipation
blurred vision
nausea
stomach upset
thickened bronchial secretions

This is not an exhaustive list. Consult your doctor if you notice any unusual symptoms.

Important Warnings

May cause marked drowsiness—avoid driving, alcohol and other sedatives. Use with caution in glaucoma, enlarged prostate/urinary retention, asthma/COPD, liver disease, and in elderly (higher risk of confusion/falls). Not recommended for children below the age advised on the label/doctor due to risk of excessive sedation and breathing problems. Do not use for persistent/chronic cough (smoking, asthma) unless advised by a doctor. Seek medical advice if symptoms persist >3–5 days, high fever, wheeze, or thick green/bloody mucus occurs.

Drug Interactions

Benadryl CR Syp may interact with the following:

Alcohol
benzodiazepines and other CNS depressants (additive sedation)
MAO inhibitors (increased anticholinergic/CNS effects)
other antihistamines/cold-cough products (duplicate therapy)
anticholinergics (increased dry mouth/urinary retention)
opioids (increased sedation/respiratory depression)

Always tell your doctor about all medicines you are taking, including over-the-counter drugs and supplements.

Pregnancy Safety

Consult doctor

Alcohol Interaction

Avoid

Habit Forming

Storage

Store below 25°C in a cool, dry place, protected from light. Keep bottle tightly closed. Keep out of reach of children.

Benadryl CR Syp — Safety Summary

Composition: Diphenhydramine hydrochloride + Ammonium chloride + Sodium citrate + Menthol (strengths vary by batch/label; refer pack for exact mg per 5 ml)
Prescription: Not required (OTC)
Pregnancy: Consult doctor
Alcohol: Avoid
Habit forming: No

Benadryl CR Syp — Safety FAQs

What should I do if I experience side effects?

Mild side effects often resolve on their own. If side effects are severe or persistent, stop the medicine and consult your doctor immediately.

Are all listed side effects common?

No. Some side effects are common while others are rare. Not everyone experiences side effects. Consult your doctor if you are concerned.

Can I take this medicine with other drugs?

Some medicines interact with each other. Always inform your doctor about all medicines you are currently taking.

When should I seek emergency help?

Seek immediate medical attention if you experience severe allergic reactions (difficulty breathing, swelling of face/throat), chest pain, or any life-threatening symptoms.

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Safety disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice. If you experience severe side effects, seek medical attention immediately.