Jubiglim M2

Composition of Jubiglim M2

Jubiglim M2 contains Glimepiride 2 mg + Metformin hydrochloride 500 mg (as sustained/prolonged release). It belongs to the Sulfonylurea + Biguanide class of medicines.

Uses of Jubiglim M2

Type 2 diabetes mellitus (adult) to improve blood sugar control when diet and exercise alone or single therapy is inadequate

Key benefits

• Lowers fasting and post-meal blood sugar
• Improves insulin sensitivity and reduces liver glucose output
• Helps achieve better HbA1c control than single therapy
• Convenient combination therapy in one tablet

How Jubiglim M2 works

Glimepiride is a sulfonylurea that increases insulin release from pancreatic beta cells and improves glucose utilization. Metformin reduces glucose production in the liver and improves insulin sensitivity, lowering blood sugar without usually causing hypoglycaemia when used alone.

How to take Jubiglim M2

Oral tablet; take exactly as prescribed. Usually taken once daily with a main meal (often breakfast or dinner). Swallow whole with water; do not crush/chew (especially if sustained/prolonged release). Monitor blood glucose regularly; follow diet and exercise advice.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can cause severe and prolonged low blood sugar, which may lead to fits or unconsciousness. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Jubiglim M2

Most side effects of Jubiglim M2 are mild and settle as the body adjusts. Reported side effects include:

• Hypoglycaemia
• nausea
• vomiting
• diarrhoea
• abdominal pain
• loss of appetite
• headache
• dizziness
• weight gain
• metallic taste

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Jubiglim M2

Warnings and precautions

Risk of hypoglycaemia (more likely with missed meals, excess exercise, alcohol, elderly, kidney/liver impairment); carry a quick source of sugar. Metformin can rarely cause lactic acidosis—seek urgent help for rapid breathing, severe weakness, muscle pain, abdominal discomfort, or unusual sleepiness. Use caution/avoid in severe renal impairment; dose adjustment and renal function monitoring required. Temporarily stop metformin before/at iodinated contrast imaging and major surgery as advised by doctor. Use caution in liver disease, heart failure, dehydration, severe infection, or alcohol misuse. Do not use in type 1 diabetes or diabetic ketoacidosis.

Do not take Jubiglim M2 if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for type 1 diabetes or for diabetic ketoacidosis. Not for people with severe kidney or liver disease. Not for people with severe kidney disease, severe liver disease, or an acute illness causing dehydration. Not for people who have had diabetic ketoacidosis.

Interactions with other medicines

Alcohol (increases risk of hypoglycaemia and lactic acidosis), insulin/other antidiabetics (additive hypoglycaemia), beta-blockers (mask hypoglycaemia symptoms), corticosteroids/thiazide diuretics/sympathomimetics (raise glucose), ACE inhibitors (may increase hypoglycaemia), fluoroquinolones (glucose disturbances), cimetidine (increases metformin levels), iodinated contrast media (risk of lactic acidosis), NSAIDs and sulfonamides (may increase hypoglycaemia), rifampicin (may reduce effect)

How to store Jubiglim M2

Store at room temperature (below 25°C), protect from moisture and light, keep in original blister pack, keep out of reach of children

Expert advice for Jubiglim M2

Take it shortly before a meal, and eat that meal. Check your sugar as often as your doctor has asked, especially when your routine changes. Take it with or just after food to reduce stomach upset. Keep taking it even when your sugar readings look normal — that is the medicine working. Continue your diet and physical activity; this medicine works alongside them, not instead of them.

Manufacturer and class

Manufacturer:

JUBILANT LIFESCIENCES

Therapeutic class:

Antidiabetic

Drug class:

Sulfonylurea + Biguanide