Drug | Tablet
Pregabalin 75 mg (sustained/extended release) tablet
Neuropathic pain (e.g., diabetic neuropathy, post-herpetic neuralgia), nerve pain associated with spinal conditions; may also be used as adjunct therapy in partial-onset seizures as prescribed
Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the CNS. This reduces release of excitatory neurotransmitters and decreases abnormal nerve signal transmission, thereby relieving neuropathic pain and reducing seizure activity.
Take by mouth once daily (OD) as prescribed, preferably at the same time each day. Swallow the tablet whole; do not crush, chew or break (modified-release). Can be taken with or without food; if it causes dizziness or sleepiness, take in the evening.
Common side effects of Pregeb M OD 75 Tablet may include:
May cause dizziness/somnolence—avoid driving or operating machinery until you know its effect. Use caution in kidney disease (dose adjustment required). Can cause swelling and weight gain; use caution in heart failure. Do not stop suddenly; taper as advised to avoid withdrawal symptoms. Rarely may cause mood changes or suicidal thoughts—seek medical help if symptoms occur. Use caution in elderly and with other CNS depressants.
