Prescription requiredAnti-asthmatic / COPD maintenance (Inhaled corticosteroid + long-acting bronchodilator)

Seroflo 125 Synchrobreathe — Side Effects & Warnings

Known side effects of Seroflo 125 Synchrobreathe include Throat irritation, hoarseness/voice change, cough, headache, oral thrush (candidiasis), nausea, tremor, palpitations, muscle cramps. Not everyone experiences these side effects.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated August 2026

Common Side Effects

Throat irritation
hoarseness/voice change
cough
headache
oral thrush (candidiasis)
nausea
tremor
palpitations
muscle cramps

This is not an exhaustive list. Consult your doctor if you notice any unusual symptoms.

Important Warnings

Not for acute bronchospasm/rapid relief. Do not exceed prescribed dose or stop abruptly without medical advice. Rinse mouth after use to reduce risk of oral thrush. Use with caution in diabetes, hyperthyroidism, cardiovascular disease/arrhythmias, hypertension, glaucoma, osteoporosis, liver impairment, and in patients with active/latent infections (e.g., tuberculosis) as steroids may worsen infections. Seek medical help if breathing worsens after inhalation (paradoxical bronchospasm) or if signs of pneumonia occur in COPD. Long-term/high-dose inhaled steroids may cause adrenal suppression and reduced bone mineral density.

Drug Interactions

Seroflo 125 Synchrobreathe may interact with the following:

Strong CYP3A4 inhibitors (ritonavir
cobicistat
ketoconazole
itraconazole
clarithromycin) may increase fluticasone/salmeterol levels and systemic steroid effects; beta-blockers may reduce bronchodilator effect; other sympathomimetics may increase cardiovascular side effects; diuretics/xanthines/corticosteroids may increase risk of hypokalemia; MAO inhibitors or tricyclic antidepressants may enhance cardiovascular effects; other LABA-containing products should be avoided.

Always tell your doctor about all medicines you are taking, including over-the-counter drugs and supplements.

Pregnancy Safety

Consult doctor

Alcohol Interaction

No known interaction

Habit Forming

Storage

Store at room temperature (below 25°C), protected from heat/direct sunlight and moisture. Keep inhaler clean and dry; do not puncture or expose to flames. Keep out of reach of children.

Seroflo 125 Synchrobreathe — Safety Summary

Composition: Salmeterol (as xinafoate) 25 mcg + Fluticasone propionate 125 mcg per metered dose (inhalation)
Prescription: Required (Rx)
Pregnancy: Consult doctor
Alcohol: No known interaction
Habit forming: No

Seroflo 125 Synchrobreathe — Safety FAQs

What should I do if I experience side effects?

Mild side effects often resolve on their own. If side effects are severe or persistent, stop the medicine and consult your doctor immediately.

Are all listed side effects common?

No. Some side effects are common while others are rare. Not everyone experiences side effects. Consult your doctor if you are concerned.

Can I take this medicine with other drugs?

Some medicines interact with each other. Always inform your doctor about all medicines you are currently taking.

When should I seek emergency help?

Seek immediate medical attention if you experience severe allergic reactions (difficulty breathing, swelling of face/throat), chest pain, or any life-threatening symptoms.

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Safety disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice. If you experience severe side effects, seek medical attention immediately.

Seroflo 125 Synchrobreathe — Side Effects & Warnings

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated August 2026